Association Between Thr21Met and Ser89Asn Polymorphisms of the Urotensin II Gene and Systemic Sclerosis

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dc.authoridDemiryurek, Abdullah/0000-0003-4762-4745
dc.authoridBayraktar, Recep/0000-0002-8227-2055
dc.authorwosidpehlivan, yavuz/AAG-8227-2021
dc.authorwosidDemiryurek, Abdullah/AAG-5244-2020
dc.authorwosidCengiz, Beyhan/AAC-8976-2022
dc.contributor.authorPehlivan, Yavuz
dc.contributor.authorGogebakan, Bulent
dc.contributor.authorOztuzcu, Serdar
dc.contributor.authorOzgen, Metin
dc.contributor.authorCetin, Gozde Yildirim
dc.contributor.authorBayraktar, Recep
dc.contributor.authorCengiz, Beyhan
dc.date.accessioned2024-06-12T11:15:56Z
dc.date.available2024-06-12T11:15:56Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective. Systemic sclerosis (SSc) is an autoimmune chronic fibrotic disorder. Urotensin II (U-IT) is predominantly a vasoactive peptide with fibrotic and prothrombotic features. Like endothelin-1 (ET-1), U-II could play an important role in SSc pathogenesis. We evaluated the possible role of the U-II gene polymorphisms (Thr21Met and Ser89Asn) in the genetic susceptibility to SSc in a Turkish population. Methods. A total of 189 patients with SSc and 205 healthy controls were enrolled in our study. We analyzed the genotype and allele frequencies of the U-II (UTS2) gene polymorphisms Thr21Met and Ser89Asn in patients with SSc and in controls. Results. We found that the Thr21Met polymorphism of the UTS2 gene was markedly associated with the risk of developing SSc (p < 0.0001), but there was no relationship between the Ser89Asn polymorphism and SSc (p > 0.05). Two haplotypes (MS and TS) were markedly associated with SSc (p < 0.05). There were significant associations between the genotype and allele frequencies of UTS2 gene Thr21Met polymorphism and cases with diffuse or limited SSc, systemic or lung involvement, finger flexion deformity, pitting scars at the fingertips, positive anticentromere, or positive antitopoisomerase I antibody groups. Conclusion. Our study shows the association between Thr21Met, but not Ser89Asn, in the UTS2 gene and SSc. The results strongly suggest that this single-nucleotide polymorphism may be an important risk factor in the development of SSc, and a powerful indicator of severe skin and lung involvement in patients with SSc. (First Release Nov I 2011; J Rheumatol 2012;39:106-11; doi:10.3899/jrheum.110509)en_US
dc.identifier.doi10.3899/jrheum.110509
dc.identifier.endpage111en_US
dc.identifier.issn0315-162X
dc.identifier.issn1499-2752
dc.identifier.issue1en_US
dc.identifier.pmid22045841en_US
dc.identifier.scopus2-s2.0-84855406054en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage106en_US
dc.identifier.urihttps://doi.org/10.3899/jrheum.110509
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24129
dc.identifier.volume39en_US
dc.identifier.wosWOS:000299400500019en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJ Rheumatol Publ Coen_US
dc.relation.ispartofJournal Of Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSYSTEMIC SCLEROSISen_US
dc.subjectUROTENSIN IIen_US
dc.subjectUROTENSIN II GENEen_US
dc.subjectType-2 Diabetes-Mellitusen_US
dc.subjectSclerodermaen_US
dc.subjectEndothelin-1en_US
dc.subjectHypertensionen_US
dc.subjectDiseasesen_US
dc.subjectJapaneseen_US
dc.subjectUts2en_US
dc.titleAssociation Between Thr21Met and Ser89Asn Polymorphisms of the Urotensin II Gene and Systemic Sclerosisen_US
dc.typeArticleen_US

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