[Effect of the levels of vascular endothelial growth factor-A and C on the prognosis of patients with laryngeal carcinoma].

Basit Öğe Kaydı
dc.authorscopusid54937497100
dc.authorscopusid7005413886
dc.authorscopusid7004457653
dc.authorscopusid20735640800
dc.authorscopusid6602357375
dc.authorscopusid6602427409
dc.authorscopusid6602899799
dc.contributor.authorDüzen B.
dc.contributor.authorTaş A.
dc.contributor.authorDemir M.
dc.contributor.authorUsta U.
dc.contributor.authorYa?iz R.
dc.contributor.authorKoten M.
dc.contributor.authorKarasaliho?lu A.
dc.date.accessioned2024-06-12T10:26:37Z
dc.date.available2024-06-12T10:26:37Z
dc.date.issued2011
dc.description.abstractIn this study, we determined the prognostic importance of vascular endothelial growth factor (VEGF)-A and C values and their relationship with tumor stages and neck lymp node involvement and also, the relationship between microvessel density and tumor stage in the pathologic specimens. Thirty-three male patients (mean age 57.8±7.2 years; range 49 to 69 years) who underwent surgical treatment for laryngeal squamous cell carcinoma and a control group of 13 healthy male subjects (mean age 54.2±6.1 years; range 41 to 62 years) were included in the study. Patients were divided into two groups: the early-stage group consisting of patients with T1 and T2 stage tumors and the advanced stage group including patients with T3 and T4 stage tumors. Patients are evaluated in terms of plasma VEGF-A and C levels before and six months after the surgery. In the pathologic specimens, CD 31 was used for immunohistochemical staining. For each patient the number of microvessels per millimeter square (microvessel density) was determined. The preoperative plasma VEBF-A levels of the patients with early-stage tumors were significantly lower compared to those of the control group, while there was no significant difference between the preoperative levels of the patients with advanced stage tumors and the levels of the control group. There was no significant difference between the preoperative and postoperative 6th month VEGF-A levels of the patients both in the early-stage and the advanced stage groups. The preoperative plasma VEGF-C values of the patients with lymph node involvement were significantly lower than those of the patients with early-stage tumors. There was no significant difference between the VEGF-C levels in pre- and postoperatively at six months after the operation of patients with lymph node involvement. There was no significant difference between the preoperative VEGF-C levels of the patients with lymph node involvement and those without lymph node involvement. No significant difference was found in microvessel density between the cases with early and advanced stage tumors. It was seen that the plasma VEGF-A value did not increase in patients with laryngeal cancer and rather it is low in patients with early-stage disease. No relationship was found between the plasma VEGF-C values and cervical lymph node involvement.en_US
dc.identifier.doi10.5606/kbbihtisas.2011.013
dc.identifier.endpage128en_US
dc.identifier.issn1300-7475
dc.identifier.issue3en_US
dc.identifier.pmid21595615en_US
dc.identifier.scopus2-s2.0-84856402475en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage122en_US
dc.identifier.urihttps://doi.org/10.5606/kbbihtisas.2011.013
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16936
dc.identifier.volume21en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.relation.ispartofKulak burun bo?az ihtisas dergisi : KBB = Journal of ear, nose, and throaten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVasculotropin A; Vasculotropin C; Vegfa Protein, Human; Vegfc Protein, Human; Adult; Aged; Article; Blood; Cancer Staging; Case Control Study; Growth, Development And Aging; Human; Laryngectomy; Larynx Tumor; Lymph Node; Lymph Node Metastasis; Male; Microvasculature; Middle Aged; Neck; Pathology; Prognosis; Squamous Cell Carcinoma; Vascularization; Adult; Aged; Carcinoma, Squamous Cell; Case-Control Studies; Humans; Laryngeal Neoplasms; Laryngectomy; Lymph Nodes; Lymphatic Metastasis; Male; Microvessels; Middle Aged; Neck; Neoplasm Staging; Prognosis; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Cen_US
dc.title[Effect of the levels of vascular endothelial growth factor-A and C on the prognosis of patients with laryngeal carcinoma].en_US
dc.title.alternativeLarenks kanserli hastalarda vasküler endotelyal büyüme faktörü A ve C düzeylerinin prognoza etkisi.en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu