Synthesis, structural aspects, antimicrobial activity and ion transportation investigation of four new [2+2] condensed 24-membered cycloheterphane peptides

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dc.authoridZaim, Omer/0000-0002-3472-5611
dc.authoridDulger, Basaran/0000-0002-3184-2652
dc.authoridDulger, Basaran/0000-0002-3184-2652
dc.authorwosidZaim, Ömer/AAI-1470-2021
dc.authorwosidPARALI, ozge/ABF-7430-2021
dc.authorwosidZaim, Omer/Q-7770-2019
dc.authorwosidDulger, Basaran/AAF-7965-2019
dc.authorwosidDulger, Basaran/J-3194-2016
dc.contributor.authorAghatabay, Naz Mohammed
dc.contributor.authorParali, Ozge
dc.contributor.authorZaim, Omer
dc.contributor.authorBaydar, Caglar
dc.contributor.authorDulger, Basaran
dc.date.accessioned2024-06-12T10:52:01Z
dc.date.available2024-06-12T10:52:01Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractFour novel [2 + 2] condensed tetramide-tetrathioether cycloheterophane (L (1) -L (4) ), possessing thioether as ligating units have been prepared. The compounds were characterized by elemental analyses, mass, FT-IR, H-1, and C-13 NMR spectral data. The 24-membered macrocycles have well organized symmetrical structures lacking any configurational isomerism. Ion transportation was carried out with macrocycle L (1) and L (4) against Na+, K+ and Ag+ cations. It showed a high propensity of binding with soft Ag+ cation that it undergoes configurational change during complexation. This phenomenon is not observed with hard cations, but K+ ion passes through the cavity while Na+ ions are retained. The antimicrobial activities of the compounds were evaluated using the disk diffusion method in dimethyl sulfoxide as well as the minimal inhibitory concentration dilution method, against several bacteria and yeast cultures. The results were compared with those of commercial antibiotic and antifungal agents. Structure activity relationships were also discussed.en_US
dc.description.sponsorshipFatih University Scientific Research Centre [P50021202_Y(2363)]; Trakya University [TUBAP-2010/174]en_US
dc.description.sponsorshipWe would like to extend our gratitude to the Fatih University Scientific Research Centre (Project-P50021202_Y(2363) and the Trakya University (Grant # TUBAP-2010/174) for their financial support. Dr. Ahmet Ceyhan Goren and Gokhan Bilsel (TUBITAK-UME), is acknowledged for the Mass analysis.en_US
dc.identifier.doi10.1007/s10847-013-0364-4
dc.identifier.endpage424en_US
dc.identifier.issn1388-3127
dc.identifier.issn1573-1111
dc.identifier.issue3-4en_US
dc.identifier.scopus2-s2.0-84904131381en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage415en_US
dc.identifier.urihttps://doi.org/10.1007/s10847-013-0364-4
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18571
dc.identifier.volume79en_US
dc.identifier.wosWOS:000339274100016en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Inclusion Phenomena And Macrocyclic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntimicrobialen_US
dc.subjectCycloheterophaneen_US
dc.subjectDiffusionen_US
dc.subjectInhibitoryen_US
dc.subjectIon Transportationen_US
dc.subjectYeasten_US
dc.subjectCyclic-Peptidesen_US
dc.subjectFt-Iren_US
dc.subjectDesignen_US
dc.subjectComplexationen_US
dc.subjectCytotoxicityen_US
dc.subjectDerivativesen_US
dc.subjectRamanen_US
dc.subjectDnaen_US
dc.titleSynthesis, structural aspects, antimicrobial activity and ion transportation investigation of four new [2+2] condensed 24-membered cycloheterphane peptidesen_US
dc.typeArticleen_US

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