Protective effects of melatonin on testicular torsion/detorsion-induced ischemia-reperfusion injury in rats

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dc.contributor.authorKanter, M.
dc.date.accessioned2024-06-12T11:08:15Z
dc.date.available2024-06-12T11:08:15Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractTesticular torsion causes an enhanced formation of reactive oxygen species, which contributes to the pathophysiology of tissue damage. The aim of this study was to investigate the protective effect of melatonin on testicular torsion/detorsion-induced ischemia-reperfusion (I/R) injury. A total of 24 male Wistar albino rats were divided into three groups of 8 animals each: control, I/R, and I/R treated with melatonin. The ischemia period was 5 h and orchiectomy was performed after 5 h of detorsion. Melatonin (10 mg/kg, intraperitoneally [i.p.]) was administrated only once, 40 min prior to detorsion. Spermatogenesis and mean seminiferous tubule diameter (MSTD) were significantly decreased in the I/R groups were compared to the control group. Furthermore, the melatonin treated animals showed an improved histological appearance in the I/R group. Our data indicate a significant reduction in the activity of TUNEL; there was a rise in the expression of proliferating cell nuclear antigen (PCNA) and testosterone in testes tissue of the I/R group treated with melatonin therapy. Electron microscopy of the testes of the rats demonstrated that pretreatment with melatonin was particularly effective in preventing mitochondrial degeneration, dilatation of SER, and enlarged intercellular spaces in both Sertoli and spermatid cells in the I/R treated animals. We believe that further preclinical research into the utility of melatonin may indicate its usefulness as a potential treatment on testes injury after I/R in rats. (C) 2010 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.yexmp.2010.07.006
dc.identifier.endpage320en_US
dc.identifier.issn0014-4800
dc.identifier.issn1096-0945
dc.identifier.issue3en_US
dc.identifier.pmid20670623en_US
dc.identifier.scopus2-s2.0-78249262577en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage314en_US
dc.identifier.urihttps://doi.org/10.1016/j.yexmp.2010.07.006
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22365
dc.identifier.volume89en_US
dc.identifier.wosWOS:000284683300016en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofExperimental And Molecular Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMelatoninen_US
dc.subjectTesticular Torsionen_US
dc.subjectTUNELen_US
dc.subjectPCNAen_US
dc.subjectUltrastructureen_US
dc.subjectCell-Specific Apoptosisen_US
dc.subjectIschemia/Reperfusion Injuryen_US
dc.subjectGerm-Cellsen_US
dc.subjectTorsionen_US
dc.subjectTestisen_US
dc.subjectTissueen_US
dc.subjectSpermatogenesisen_US
dc.subjectProliferationen_US
dc.subjectCalpainen_US
dc.subjectCyclinen_US
dc.titleProtective effects of melatonin on testicular torsion/detorsion-induced ischemia-reperfusion injury in ratsen_US
dc.typeArticleen_US

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