The Effects of Irisin on N?-Nitro-L-arginine Methyl Ester Hydrochloride-Induced Hypertension in Rats

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dc.contributor.authorAydoğdu, Nurettin
dc.contributor.authorYavuz, Özlem Yalçınkaya
dc.contributor.authorTaştekin, Ebru
dc.contributor.authorTayfur, Pınar
dc.contributor.authorKaya, Oktay
dc.contributor.authorKandemir, Nihayet
dc.date.accessioned2021-11-20T10:10:07Z
dc.date.available2021-11-20T10:10:07Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: The cause of about 95% of hypertension, an important public health problem, is unknown. Intensive studies are underway to understand the physiopathology of hypertension. Irisin, a newly discovered hormone, has been reported to dilate vascular smooth muscle and lower blood pressure acutely. Aims: To investigate the effects of chronic irisin treatment on blood pressure and renal functions in a hypertension model established by nitric oxide synthase inhibition by treatment with N?-nitro-L-arginine methyl ester hydrochloride. Study Design: Animal experimentation. Methods: Male Sprague?Dawley rats were divided into four groups (n=8). Control and irisin groups received an intravenous saline injection, hypertension and hypertension + irisin (hypertension + irisin) groups received 1.5 mg/100 g N?-nitro-L-arginine methyl ester hydrochloride. N?-nitro-L-arginine methyl ester hydrochloride (150 mg/L) was added to the drinking water of rats in groups hypertension and hypertension + irisin for three weeks. In the second week of the experiment, irisin (50 nmol/day) was given to rats in groups irisin and hypertension + irisin, and saline was administered to rats in groups control and hypertension for two weeks through subcutaneously placed osmotic minipumps. Blood pressure was measured by the tail-cuff plethysmography method. On the twenty-first day of the experiment, 24-hour urine, blood, and both kidneys of the rats were collected. Results: The hypertension group had elevated systolic, diastolic, and mean arterial blood pressure values compared with the control group, with decreased glutathione levels in tissue and serum, but an increase in serum oxidized glutathione level (p<0.05). Histopathologically, increased tubular injury, cast formation, glomerular sclerosis, and peritubular fibrosis levels were observed (p<0.05). Irisin treatment did not cause any significant change in blood pressure, renal functions, and injury scores. However, renal nitric oxide levels significantly increased, and endothelial nitric oxide synthase immunoreactivity was determined to be reduced (p<0.05). Conclusion: Treatment with chronic irisin at a physiological dose does not reduce blood pressure in an experimental model of hypertension. In different models of experimental hypertension, the effects of irisin administration at different doses and at different periods should be thoroughly investigated.en_US
dc.identifier.doi10.4274/balkanmedj.galenos.2019.2019.5.113en_US
dc.identifier.endpage346en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue6en_US
dc.identifier.pmid31486326en_US
dc.identifier.scopus2-s2.0-85074118777en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage337en_US
dc.identifier.trdizinid319488en_US
dc.identifier.urihttps://doi.org/10.4274/balkanmedj.galenos.2019.2019.5.113
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpFNU5EZzRPQT09
dc.identifier.urihttps://hdl.handle.net/20.500.14551/5520
dc.identifier.volume36en_US
dc.identifier.wosWOS:000492395100007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240608_ID_Qen_US
dc.subjectKlinik Nörolojien_US
dc.subjectSağlık Bilimleri ve Hizmetlerien_US
dc.subjectTıbbi İnformatiken_US
dc.subjectGenel ve Dahili Tıpen_US
dc.subjectTıbbi Araştırmalar Deneyselen_US
dc.subjectTemel Sağlık Hizmetlerien_US
dc.subjectCerrahien_US
dc.titleThe Effects of Irisin on N?-Nitro-L-arginine Methyl Ester Hydrochloride-Induced Hypertension in Ratsen_US
dc.typeArticleen_US

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