Effects of Nigella sativa seed extract on ameliorating lung tissue damage in rats after experimental pulmonary aspirations

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dc.contributor.authorKanter, Mehmet
dc.date.accessioned2024-06-12T11:13:07Z
dc.date.available2024-06-12T11:13:07Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAspiration of gastric contents can cause serious lung injury, although the mechanisms of pulmonary damage are still not clear and means of amelioration of the pulmonary damage have been little investigated. The black cumin seed, Nigella sativa L. (NS) has been shown to have specific health benefits and the aim of the current study was to investigate the possible beneficial effects of NS on experimental lung injury in male Wistar rats after pulmonary aspiration of different materials. The rats were randomly allotted into one of six experimental groups (n = 7 per group): (1) saline control, (2) saline+NS treated, (3) Pulmocare (a specialized nutritional supplement given to pulmonary patients), (4) Pulmocare+NS treated, (5) hydrochloric acid, (6) hydrochloric acid+NS treated. The saline, Pulmocare and hydrochloric acid were injected into the lungs in a volume of 2 ml/kg. The rats received daily oral doses of NS volatile oil (400mg/kg body weight) by means of intragastric intubation for 7 days starting immediately after the pulmonary aspiration of the materials. After 7 days, the rats were sacrificed and tissue samples from both lungs were taken for histopathological investigation. To date, no similar study investigating the potential for NS treatment to protect against lung injury after pulmonary aspiration of materials has been reported. Our study showed that NS treatment inhibits the inflammatory pulmonary responses, reducing significantly (p<0.05) peribronchial inflammatory cell infiltration, alveolar septal infiltration, alveolar edema, alveolar exudate, alveolar macrophages, interstitial fibrosis, granuloma and necrosis formation in different pulmonary aspiration models. Our data indicate a significant reduction in the activity of inducible nitric oxide synthase (iNOS) and a rise in surfactant protein D in lung tissue of different pulmonary aspiration models after NS therapy. Based on our results, we conclude that NS treatment might be beneficial in lung injury and have potential clinical use. (C) 2009 Elsevier GmbH. All rights reserved.en_US
dc.identifier.doi10.1016/j.acthis.2008.10.008
dc.identifier.endpage403en_US
dc.identifier.issn0065-1281
dc.identifier.issn1618-0372
dc.identifier.issue5en_US
dc.identifier.pmid19428057en_US
dc.identifier.scopus2-s2.0-67349264103en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage393en_US
dc.identifier.urihttps://doi.org/10.1016/j.acthis.2008.10.008
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23429
dc.identifier.volume111en_US
dc.identifier.wosWOS:000267853000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Gmbhen_US
dc.relation.ispartofActa Histochemicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPulmonary Aspirationen_US
dc.subjectAcute Lung Injuryen_US
dc.subjectInosen_US
dc.subjectSurfactant Protein Den_US
dc.subjectNigella Sativaen_US
dc.subjectRatsen_US
dc.subjectNitric-Oxide Synthaseen_US
dc.subjectAlveolar Macrophagesen_US
dc.subjectEnteral Solutionsen_US
dc.subjectGastric Contentsen_US
dc.subjectInjuryen_US
dc.subjectPneumoniaen_US
dc.subjectInhibitionen_US
dc.subjectOilen_US
dc.titleEffects of Nigella sativa seed extract on ameliorating lung tissue damage in rats after experimental pulmonary aspirationsen_US
dc.typeArticleen_US

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