Expression of Bcl-2 and Ki-67 in tamoxifen-associated endometrial polyps: Comparison with postmenopausal polyps

Basit Öğe Kaydı
dc.authoridÖzdemir, Çiğdem/0000-0001-8500-0744
dc.authoridOz Puyan, Fulya/0000-0001-5853-0109
dc.authoridPuyan, Fulya/0000-0001-5853-0109
dc.authorwosidÖzdemir, Çiğdem/HNQ-6804-2023
dc.authorwosidOz Puyan, Fulya/A-7077-2018
dc.authorwosidPuyan, Fulya/V-7074-2019
dc.contributor.authorAltaner, Semsi
dc.contributor.authorGucer, Fatih
dc.contributor.authorTokatli, Fusun
dc.contributor.authorGuresci, Servet
dc.contributor.authorOzdemir, Cigdem
dc.contributor.authorPuyan, Fulya Oz
dc.contributor.authorKutlu, Kemal
dc.date.accessioned2024-06-12T11:12:35Z
dc.date.available2024-06-12T11:12:35Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: The aim of this study was to evaluate the expression of Bcl-2 and Ki-67 in tamoxifen (TAM)-associated endometrial polyps and postmenopausal polyps. Material and Methods: For this purpose, a retrospective analysis of paraffin-embedded specimens was carried out. Polyps of 20 postmenopausal and 14 TAM-treated patients, 11 simple endometrial hyperplasia, 10 atypical complex endometrial hyperplasia and 8 endometrial adenocarcinoma specimens were included in the study. Hematoxylin/eosin-stained sections were evaluated. Immunohistochemical staining was performed to investigate the expression of Bcl-2 protein and the Ki-67 proliferation index. Results: There was no statistically significant difference between the 5 groups with regard to Bcl-2 staining (p > 0.05). However, Bcl-2 expression in TAM-associated polyps was higher (86%) than in the postmenopausal control group (80%). Positive Ki-67 was highest in the endometrial adenocarcinoma specimens, followed by the atypical complex endometrial hyperplasia group (p < 0.0001). Compared to these 2 groups, Ki-67 expression was lower in TAM-associated polyps, but Ki-67 indexes were significantly higher in the TAM-associated group than in the control group (p < 0.0001). Conclusion: Since TAM-associated polyps tend to have higher proliferation indexes and Ki-67 ratios than control groups, we suggest that they are likely to have a higher malignant potential.en_US
dc.identifier.doi10.1159/000094443
dc.identifier.endpage380en_US
dc.identifier.issn0378-584X
dc.identifier.issn1423-0240
dc.identifier.issue8-9en_US
dc.identifier.pmid16974115en_US
dc.identifier.scopus2-s2.0-33748571184en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage376en_US
dc.identifier.urihttps://doi.org/10.1159/000094443
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23228
dc.identifier.volume29en_US
dc.identifier.wosWOS:000241943800005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofOnkologieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPolyps : Endometrial, Postmenopausalen_US
dc.subjectTamoxifenen_US
dc.subjectBcl-2en_US
dc.subjectKi-67en_US
dc.subjectBreast-Cancer Patientsen_US
dc.subjectProgesteroneen_US
dc.subjectPathologiesen_US
dc.subjectReceptorsen_US
dc.subjectTherapyen_US
dc.titleExpression of Bcl-2 and Ki-67 in tamoxifen-associated endometrial polyps: Comparison with postmenopausal polypsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu