Assessment of Cota altissima (L.) J. Gay for phytochemical composition and antioxidant, anti-inflammatory, antidiabetic and antimicrobial activities

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dc.authoridGoger, Gamze/0000-0003-2978-5385
dc.authoridGöger, Fatih/0000-0002-9665-0256
dc.authorwosidGoger, Gamze/JCE-6911-2023
dc.authorwosidGöger, Fatih/HTR-3454-2023
dc.contributor.authorGoger, Gamze
dc.contributor.authorAllak, Muhammed
dc.contributor.authorSen, Ali
dc.contributor.authorGoger, Fatih
dc.contributor.authorTekin, Mehmet
dc.contributor.authorOzek, Gulmira
dc.date.accessioned2024-06-12T10:50:30Z
dc.date.available2024-06-12T10:50:30Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPhytochemical profiles of essential oil (EO), fatty acids, and n-hexane (CAH), diethyl ether (CAD), ethyl acetate (CAE) and methanol extracts (CAM) of Cota altissima L. J. Gay (syn. Anthemis altissima L.) were investigated as well as their antioxidant, anti-inflammatory, antidiabetic and antimicrobial activites. The essential oil was characterized by the content of acetophenone (35.8%) and beta-caryophyllene (10.3%) by GC-MS/FID. Linoleic and oleic acid were found as main fatty acids. The major constituents of the extracts were found to be 5-caffeoylquinic acid, 3,5-dicaffeoylquinic acid, isorhamnetin glucoside, quercetin and quercetin glucoside by LC-MS/MS. Antioxidant activities of the extracts were determined by scavenging of DPPH and ABTS free radicals. Also, the inhibitory effects on lipoxygenase and alpha-glucosidase enzymes were determined. Antimicrobial activity was evaluated against Gram positive, Gram negative bacteria and yeast pathogens. CAM showed the highest antioxidant activity against DPPH and ABTS radicals with IC50 values of 126.60 and 144.40 mu g/mL, respectively. In the anti-inflammatory activity, CAE demonstrated the highest antilipoxygenase activity with an IC50 value of 105.40 mu g/mL, whereas, CAD showed the best inhibition of a-glucosidase with an IC50 value of 396.40 mu g/mL in the antidiabetic activity. CAH was effective against Staphylococcus aureus at MIC = 312.5 mu g/mL. This is the first report on antidiabetic, anti-inflammatory and antimicrobial activities of different extracts of C. altissima.en_US
dc.description.sponsorshipTubitak [SBAG 218S812]en_US
dc.description.sponsorshipThis work was partionally supported by the Tubitak SBAG 218S812.en_US
dc.identifier.doi10.1515/znc-2020-0257
dc.identifier.endpage327en_US
dc.identifier.issn0939-5075
dc.identifier.issn1865-7125
dc.identifier.issue7-8en_US
dc.identifier.pmid33559461en_US
dc.identifier.scopus2-s2.0-85101045122en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage317en_US
dc.identifier.urihttps://doi.org/10.1515/znc-2020-0257
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18027
dc.identifier.volume76en_US
dc.identifier.wosWOS:000672580800006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofZeitschrift Fur Naturforschung Section C-A Journal Of Biosciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectActivityen_US
dc.subjectCota Altissimaen_US
dc.subjectEssential Oilen_US
dc.subjectExtracten_US
dc.subjectGC-MS/FIDen_US
dc.subjectLC-MS/MSen_US
dc.subjectChemical-Compositionen_US
dc.subjectEssential Oilen_US
dc.subjectAnthemis-Altissimaen_US
dc.subjectInhibitory-Activitiesen_US
dc.subjectAciden_US
dc.subjectClassificationen_US
dc.subjectWiedemannianaen_US
dc.subjectChrysanthemumen_US
dc.subjectCultivarsen_US
dc.subjectProfilesen_US
dc.titleAssessment of Cota altissima (L.) J. Gay for phytochemical composition and antioxidant, anti-inflammatory, antidiabetic and antimicrobial activitiesen_US
dc.typeArticleen_US

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