Myocarditis associated with immune checkpoint inhibitors: Practical considerations in diagnosis and management

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dc.contributor.authorGurdogan, Muhammet
dc.contributor.authorYalta, Kenan
dc.date.accessioned2024-06-12T10:55:45Z
dc.date.available2024-06-12T10:55:45Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractImmune checkpoint inhibitors (ICI) have caused radical changes in the treatment scheme of many types of cancer in the past 10 years. ICIs are specific monoclonal antibodies that increase T-cell mediated immune response against cancer cells. Despite important advances in cancer treatment, uncontrolled activation of cytotoxic T cells has brought along many autoimmune clinical side effects, especially acute myocarditis. Although the incidence of ICI-related myocarditis is about 1%, it is remarkable in terms of mortality rate reaching 46% and demonstrating the necessity of rapid diagnosis and multidisciplinary approach. The present review aimed to summarize the heterogeneous symptomatology of ICI-associated myocarditis, clinical presentation ranging from elevated asymptomatic cardiac enzyme levels to cardiogenic shock, prominent diagnostic value of cardiac magnetic resonance imaging, and current information on the effectiveness of immunosuppressants in therapy.en_US
dc.identifier.doi10.14744/AnatolJCardiol.2020.79584
dc.identifier.endpage75en_US
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue2en_US
dc.identifier.pmid32749254en_US
dc.identifier.scopus2-s2.0-85089164493en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage68en_US
dc.identifier.trdizinid375347en_US
dc.identifier.urihttps://doi.org/10.14744/AnatolJCardiol.2020.79584
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/375347
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19547
dc.identifier.volume24en_US
dc.identifier.wosWOS:000556602000004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Soc Cardiologyen_US
dc.relation.ispartofAnatolian Journal Of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCardiotoxicityen_US
dc.subjectImmune Checkpoint Inhibitoren_US
dc.subjectMyocarditisen_US
dc.subjectImmunotherapyen_US
dc.subjectSurvivalen_US
dc.subjectTherapyen_US
dc.subjectFailureen_US
dc.titleMyocarditis associated with immune checkpoint inhibitors: Practical considerations in diagnosis and managementen_US
dc.typeReview Articleen_US

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