Protective effects of proanthocyanidin and vitamin E against toxic effects of formaldehyde in kidney tissue

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dc.authoridCerkezkayabekir, Aysegul/0000-0001-5537-1042
dc.authoridUlucam, Enis/0000-0002-4686-7350
dc.authorwosidUluçam, Enis/HQZ-3831-2023
dc.authorwosidBAKAR, Elvan/AAE-9247-2022
dc.authorwosidCerkezkayabekir, Aysegul/Q-6629-2018
dc.authorwosidUlucam, Enis/AAG-9204-2019
dc.contributor.authorBakar, E.
dc.contributor.authorUlucam, E.
dc.contributor.authorCerkezkayabekir, A.
dc.date.accessioned2024-06-12T10:54:14Z
dc.date.available2024-06-12T10:54:14Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractWe investigated possible effects of proanthocyanidin (PA) and vitamin E on damage to rat kidneys induced by formaldehyde (FA), using biochemical characteristics and light and electron microscopy. Male rats were divided into control, FA, PA and vitamin E treated groups. Kidney tissue was observed by light and electron microscopy. Bcl-2/Bax rate was measured using immunohistochemistry. Malondialdehyde (MDA) and total sialic acid (TSA) levels, superoxide dismutase (SOD), glutathione peroxidase (Gpx), catalase (CAT) and myeloperoxidase (MPO) activities were measured. We found that FA caused damage to the parietal epithelial layer of the glomerulus, mononuclear cell infiltration, membrane damage in renal tubules, pyknotic nuclei, hypertrophic cells in Henle's loop and tubules, and loss of renal tubule integrity. We also observed invagination of the nuclear membrane, irregularity of chromatin material and loss of mitochondrial cristae. We observed increased Bcl-2 and Bax immunostaining in the FA group, but the Bcl-2/Bax rate remained unchanged in FA, PA and vitamin E groups compared to controls. Tissue MDA and TSA levels, and CAT and Gpx activities were increased, and SOD and MPO activities were decreased by FA toxicity. We observed a protective effect of PA in tissue MDA and TSA levels and SOD activities, because there was no difference in the PA group compared to the control group. We investigated the antioxidant effects of PA and vitamin E and found protective effects of PA against apoptosis.en_US
dc.description.sponsorshipTrakya University Scientific Research Projects Unit [TUBAP-2011-88]en_US
dc.description.sponsorshipThis research, project No: TUBAP-2011-88, was conducted with the financial support of Trakya University Scientific Research Projects Unit.en_US
dc.identifier.doi10.3109/10520295.2014.954620
dc.identifier.endpage78en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue1en_US
dc.identifier.pmid25225844en_US
dc.identifier.scopus2-s2.0-84919458712en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage69en_US
dc.identifier.urihttps://doi.org/10.3109/10520295.2014.954620
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18980
dc.identifier.volume90en_US
dc.identifier.wosWOS:000351942200009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBaxen_US
dc.subjectBcl-2en_US
dc.subjectFormaldehydeen_US
dc.subjectKidneyen_US
dc.subjectOxidative Stressen_US
dc.subjectProanthocyanidinen_US
dc.subjectEssential Fatty-Acidsen_US
dc.subjectOxidative Damageen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectSialic Acidsen_US
dc.subjectEndoplasmic-Reticulumen_US
dc.subjectProcyanidin Extracten_US
dc.subjectPrefrontal Cortexen_US
dc.subjectFree-Radicalsen_US
dc.subjectApoptosisen_US
dc.subjectStressen_US
dc.titleProtective effects of proanthocyanidin and vitamin E against toxic effects of formaldehyde in kidney tissueen_US
dc.typeArticleen_US

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