Arterial distensibility in Wegener's granulomatosis: A carotid-femoral pulse wave velocity study
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Tarih
2007
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Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: The purpose of this study was to test the hypothesis; that chronic inflammation may impair vascular function and lead to an increase of arterial pulse wave velocity (PWV) in patients with Wegener's granulomatosis (WG). Methods: We recruited 5 patients with WG and 5 healthy age and sex matched controls in this cross-sectional case-controlled study. Aortic PWV was determined by using an automatic device (Complior Colson, France), which allowed on-line pulse wave recording and automatic calculation of PWV. Results: The carotid-femoral (aortic) PWV was increased in patients with WG as compared with control group (p=0.04). Although we found positive correlation between PWV and heart rate (r=0.75, p=0.01), we did not find any significant correlation between PWV and anthropometric and other hemodynamic parameters (p>0.05). In addition, we found positive correlation between PWV and erythrocyte sedimentation rate in patients with WG (r=0.90, p=0.03). Conclusion: Pulse wave velocity is increased and arterial distensibility decreased in patients with WG. Measurements of carotid-femoral (aortic) PWV may provide an easy and noninvasive technique to identify patients at increased risk of arterial disease.
Açıklama
Anahtar Kelimeler
Arterial Distensibility; Inflammation; Pulse Wave Velocity; Wegener's Granulomatosis, Antiinflammatory Agent; Azathioprine; Cyclophosphamide; Cytotoxic Agent; Prednisolone; Adult; Anthropometry; Artery Compliance; Artery Disease; Article; Blood Vessel Function; Carotid Artery; Case Control Study; Chronic Inflammation; Clinical Article; Controlled Study; Correlation Analysis; Device; Erythrocyte Sedimentation Rate; Female; Femoral Artery; Hemodynamics; Human; Hypothesis; Male; Non Invasive Procedure; Online Analysis; Patient Identification; Pulse Wave; Risk Assessment; Wegener Granulomatosis; Blood Flow Velocity; Blood Sedimentation; Cardiovascular Diseases; Carotid Arteries; Case-Control Studies; Cross-Sectional Studies; Female; Femoral Artery; Humans; Male; Middle Aged; Pulsatile Flow; Wegener Granulomatosis
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N/A
Cilt
7
Sayı
3
