Comparison of the effects of letrozole and clompiphene citrate on ovarian follicles, endometrium, and hormone levels in the rat

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dc.contributor.authorKilic-Okman, T
dc.contributor.authorKucuk, M
dc.contributor.authorAltaner, S
dc.date.accessioned2024-06-12T11:07:37Z
dc.date.available2024-06-12T11:07:37Z
dc.date.issued2003
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: To compare the effects of letrozole and clomiphene citrate in the rat in terms of number of ovarian follicles; endometrial thickness; and serum levels of E-2, FSH, LH, and T. Design: Controlled prospective study. Setting: University research laboratory. Animal(s): Thirty sexually mature female Wistar-Albino rats that were 20 weeks of age. Intervention(s): Letrozole, 5 mg/kg of body weight daily (10 rats); clomiphene citrate, 100 mug/kg daily (10 rats); or saline solution, 2 mL/d (10 rats). After 2 days, rats were euthanized and ovariectomized. Main Outcome Measure(s): Number of mature follicles, endometrial thickness, and serum levels of hormones. Result(s): Mean levels of FSH, LH, E2, and T; number of mature follicles; and ovary size differed among the groups, whereas the mean endometrial thickness did not differ. Conclusion(s): In rats, the effect of letrozole on follicular maturation is similar to that of clomiphene citrate. (C) 2003 by American Society for Reproductive Medicine.en_US
dc.identifier.doi10.1016/j.fertnstert.2003.05.002
dc.identifier.endpage1332en_US
dc.identifier.issn0015-0282
dc.identifier.issue6en_US
dc.identifier.pmid14667861en_US
dc.identifier.scopus2-s2.0-0346366909en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1330en_US
dc.identifier.urihttps://doi.org/10.1016/j.fertnstert.2003.05.002
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22111
dc.identifier.volume80en_US
dc.identifier.wosWOS:000187284200003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofFertility And Sterilityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLetrozoleen_US
dc.subjectRaten_US
dc.subjectClomipheneen_US
dc.subjectEndometriumen_US
dc.subjectFollicleen_US
dc.subjectOvaryen_US
dc.subjectClomiphene Citrateen_US
dc.subjectStimulating-Hormoneen_US
dc.subjectAromatase Inhibitoren_US
dc.subjectWomenen_US
dc.subjectEstrogenen_US
dc.titleComparison of the effects of letrozole and clompiphene citrate on ovarian follicles, endometrium, and hormone levels in the raten_US
dc.typeArticleen_US

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