Solubilization Effect of Anionic, Cationic and Nonionic Surfactants on Coenzyme Q10 Solid Dispersion

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dc.authorwosidErgin, Ahmet Dogan/AAO-1876-2021
dc.contributor.authorErgin, Ahmet Dogan
dc.date.accessioned2024-06-12T10:58:02Z
dc.date.available2024-06-12T10:58:02Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractCoenzyme Q10 (CoQ10) is an oil-soluble vitamin-like benzoquinone compound. Coenzyme Q10 plays a role in providing membrane stability, energy conversion and ATP production. It is also one of the important antioxidants in the body. The bioavailability of coenzyme Q10 is very low due to its low solubility in water and its large molecular mass. Among the solubility enhancement approaches, solid dispersions (SDs) are one of the most promising strategies. The use of suitable carrier and methodology plays a significant role in the biological response. In terms of a carrier, solid dispersions are classified broadly the third group. Surfactant-based SDs are called third-generation solid dispersions. To evaluate the surfactant effect on solubilization of CoQ10, three different surfactants of varying ratios between 1:1, 1:3 and 1:5 (w/w) were used namely sodium dodecylsulfate (SDS) (anionic), cetyl trimethyl ammonium bromide (CTAB) (cationic) and Pluronic F127 (non-ionic). CoQ10 solid dispersions were characterized in terms of particle size, polydispersity index, zeta potential, FTIR spectroscopy, DSC analysis, saturation solubility and in vitro dissolution studies. To compare dissolution rate, area under the dissolution curve (AUC), Mean Dissolution Time (MDT), mean residence time of the drug substance molecules in the dosage form (MRT), and dissolutio nefficiency % (DE%) were calculated. All the formulations showed improvement in the aqueous solubility, while the dissolution rate was increased only by Pluronic F127 (p<0.05). Among the surfactants, Pluronic F127-based SDs were found superior to other surfactants. The results revealed that surfactant-based SDs offered great success in improving the therapeutic efficacy of CoQ10.en_US
dc.description.sponsorshipTrakya University Scientific and Technological Research Council [2021/23]en_US
dc.description.sponsorshipThis study was supported by the Trakya University Scientific and Technological Research Council under grant 2021/23.en_US
dc.identifier.doi10.29228/jrp.403
dc.identifier.endpage1133en_US
dc.identifier.issn2630-6344
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85161467518en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1120en_US
dc.identifier.trdizinid1179447en_US
dc.identifier.urihttps://doi.org/10.29228/jrp.403
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1179447
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19906
dc.identifier.volume27en_US
dc.identifier.wosWOS:001011434600013en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherMarmara Univen_US
dc.relation.ispartofJournal Of Research In Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCoenzyme Q10en_US
dc.subjectSolid Dispersionen_US
dc.subjectSodium Lauryl Sulfate (SLS)en_US
dc.subjectCetyltrimethylammonium Bromide(CTAB)en_US
dc.subjectPluronic F127en_US
dc.subjectPhysicochemical Characterizationen_US
dc.subjectIn-Vitroen_US
dc.subjectDissolutionen_US
dc.subjectBioavailabilityen_US
dc.subjectCarrieren_US
dc.subjectFormulationen_US
dc.subjectAbsorptionen_US
dc.subjectTacrolimusen_US
dc.subjectStrategiesen_US
dc.subjectDeliveryen_US
dc.titleSolubilization Effect of Anionic, Cationic and Nonionic Surfactants on Coenzyme Q10 Solid Dispersionen_US
dc.typeArticleen_US

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