The effect of swimming exercise on adenineinduced kidney disease in rats, and the influence of curcumin or lisinopril thereon

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dc.authoridKARACA, Turan/0000-0002-2500-7781
dc.authoridAl Za'abi, Mohammed/0000-0002-2019-1022
dc.authoridAshique, Mohammed/0000-0002-3132-1478
dc.authoridAli, Badreldin/0000-0001-6491-6278
dc.authorwosidKARACA, Turan/ABD-6669-2020
dc.authorwosidAl Za'abi, Mohammed/C-6591-2013
dc.contributor.authorAli, Badreldin H.
dc.contributor.authorKaraca, Turan
dc.contributor.authorAl Suleimani, Yousuf
dc.contributor.authorAl Za'abi, Mohammed
dc.contributor.authorAl Kalbani, Jamila
dc.contributor.authorAshique, Mohammed
dc.contributor.authorNemmar, Abderrahim
dc.date.accessioned2024-06-12T11:17:29Z
dc.date.available2024-06-12T11:17:29Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPatients with chronic kidney disease (CKD) have been reported to benefit from different types of exercises. It has also been shown that the ACE inhibitor lisinopril, and the natural product curcumin are also beneficial in different models of CKD in rats. We assessed the influence of moderate swimming exercise (SE) on rats with adenine- induced CKD, and tested the possible effects of lisinopril and/or curcumin thereon using several physiological, biochemical, histopathological and immunohistochemical parameters. Rats (either sedentary or subjected to SE) were randomly divided into several groups, and given for five weeks either normal food or food mixed with adenine (0.25% w/w) to induce CKD. Some of these groups were also concomitantly treated orally with curcumin (75 mg/kg), or lisinopril (10 mg/kg) and were subjected to moderate SE (45 min/day three days each week). Rats fed adenine showed the typical biochemical, histopathological signs of CKD such as elevations in blood pressure, urinary albumin / creatinine ratio, and plasma urea, creatinine, indoxyl sulfate and phosphorus. SE, curcumin or lisinopril, given singly, significantly ameliorated all the adenine-induced actions. Administering curcumin or lisinopril with SE improved the histopathology of the kidneys, a salutary effect not seen with SE alone. Combining SE to the nephroprotective agents' curcumin or lisinopril might offer additional nephroprotection.en_US
dc.description.sponsorshipResearch Council of Oman [REC/MED/PHARM/13/01]en_US
dc.description.sponsorshipThis study was financially supported by the Research Council of Oman (REC/MED/PHARM/13/01). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en_US
dc.identifier.doi10.1371/journal.pone.0176316
dc.identifier.issn1932-6203
dc.identifier.issue4en_US
dc.identifier.pmid28445490en_US
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0176316
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24724
dc.identifier.volume12en_US
dc.identifier.wosWOS:000400309200045en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPublic Library Scienceen_US
dc.relation.ispartofPlos Oneen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject5/6 Nephrectomized Ratsen_US
dc.subjectChronic-Renal-Failureen_US
dc.subjectOxidative Stressen_US
dc.subjectCardiovascular Protectionen_US
dc.subjectSedentary Behaviorsen_US
dc.subjectPhysical-Activityen_US
dc.subjectHypertensionen_US
dc.subjectInflammationen_US
dc.subjectFibrosisen_US
dc.subjectInjuryen_US
dc.titleThe effect of swimming exercise on adenineinduced kidney disease in rats, and the influence of curcumin or lisinopril thereonen_US
dc.typeArticleen_US

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