Dobutamine induced dynamic left ventricular outflow tract obstruction in patients with hypertrophic nonobstructive cardiomyopathy

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dc.authoridOZER TEKIN, N. Beril/0000-0002-1402-7891
dc.authoridbolca, osman/0000-0003-0156-3991
dc.authoridDagdeviren, Bahadir/0000-0001-6945-0745
dc.authoridEren, Mehmet/0000-0002-5570-705X
dc.authorwosidOZER TEKIN, N. Beril/Y-1573-2018
dc.authorwosidbolca, osman/JYP-8138-2024
dc.authorwosidDagdeviren, Bahadir/J-5016-2012
dc.authorwosidEren, Mehmet/ACD-8031-2022
dc.contributor.authorBolca, O
dc.contributor.authorÖzer, N
dc.contributor.authorEren, M
dc.contributor.authorDagdeviren, B
dc.contributor.authorNorgaz, T
dc.contributor.authorAkdemir, O
dc.contributor.authorTezel, T
dc.date.accessioned2024-06-12T10:59:42Z
dc.date.available2024-06-12T10:59:42Z
dc.date.issued2002
dc.departmentTrakya Üniversitesien_US
dc.description.abstractSome patients with hypertrophic nonobstructive cardiomyopathy (HNCM) suffer symptoms resembling those in obstructive type despite no left ventricular outflow tract (LVOT) gradient could be detected on resting echocardiography. To investigate the value of dobutamine stress echocardiography (DSE) in determining the dynamic left ventricular (LV) obstruction of patients with HNCM. The study was conducted on 31 patients who were diagnosed HNCM on resting echocardiography and 9 healthy person as a control group. Intraventricular flow acceleration of > 3 m/sec on DSE was accepted as dynamic LVOT obstruction. Group I and 2 included patients without and with dynamic LVOT obstruction, respectively. The occurrence of chest pain and dyspnea seen during DSE was more frequent in group 2 than group 1 and control group. The frequency of SAM was significantly higher (p < 0.05) and the septal angle was significantly lower (p < 0.001) in Group 2. The presence of SAM significantly correlated with the peak gradient (r = 0.61, p < 0.001). The septal angle had significant negative correlations with the peak gradient (r = .-0.77, p < 0.001) reached at DSE. The relative risk for peak gradient was highest when septal angle was less than or equal to 100degrees, with a sensitivity of 93%, specificity of 80%, positive predictive value of 82%, negative predictive value of 92%, and predictive accuracy of 87%. DSE is a reliable tool for the diagnosis of dynamic LV obstruction in patients with HNCM. The presence of SAM together with a low septal angle is highly predictive for the presence of a dynamic LVOT obstruction detected by DSE. (C) 2002 Tohoku University Medical Press.en_US
dc.identifier.doi10.1620/tjem.198.79
dc.identifier.endpage87en_US
dc.identifier.issn0040-8727
dc.identifier.issn1349-3329
dc.identifier.issue2en_US
dc.identifier.pmid12512992en_US
dc.identifier.scopus2-s2.0-12244249235en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage79en_US
dc.identifier.urihttps://doi.org/10.1620/tjem.198.79
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20551
dc.identifier.volume198en_US
dc.identifier.wosWOS:000180020800002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTohoku Univ Medical Pressen_US
dc.relation.ispartofTohoku Journal Of Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDobutamine Stress Echocardiographyen_US
dc.subjectHypertrophic Nonobstructive Cardiomyopathyen_US
dc.subjectDynamic Obstructionen_US
dc.subjectSystolic Anterior Motionen_US
dc.subjectStress Echocardiographyen_US
dc.subjectPrevalenceen_US
dc.subjectGradienten_US
dc.titleDobutamine induced dynamic left ventricular outflow tract obstruction in patients with hypertrophic nonobstructive cardiomyopathyen_US
dc.typeArticleen_US

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