The relation between the storage symptoms before and after transurethral resection of the prostate, analysis of the risk factors and the prevention of the symptoms with solifenacin

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dc.authoridSIPAL, TIMUCIN/0000-0003-3992-2013
dc.contributor.authorSipal, Timucin
dc.contributor.authorAkdere, Hakan
dc.date.accessioned2024-06-12T11:16:37Z
dc.date.available2024-06-12T11:16:37Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective and Hypothesis: We aimed to investigate the reasons of storage symptoms ( SS) after transurethral resection of the prostate (TURP). The hypothesis was that a positive correlation would be identified between preoperative and postoperative SS in patients with undergoing TURP and starting early solifenacin treatment in patients with high preoperative SS would be reasonable. In addition, we aimed to analyze multiple other risk factors for post-TURP SS. Materials and Methods: A total of 160 patients undergoing TURP were prospectively evaluated and divided into two groups according to their OABS. Those with a score of >= 10 points were Group 1 (G1), and those with <10 points Group 2 (G2). In addition, patients in each group were randomly further divided into two subgroups: those who were started on 5 mg solifenacin succinate in the early postoperative period (G1/G2 A) and those who were not (G1/G2 B). In additions to SS Preop, perop and at the 3rd-month of postoperatively 14 variable were evaluated. The effects of these factors, surgery and the efficacy of an early medical treatment on the postoperative SS were investigated. LUTS were assessed by International Prostate Symptom Score (IPSS) and SS were assessed by sum of IPSS 2, 4 and 7 questionnaires (Storage, S- IPSS). Results: Preoperative IPSS and S-IPSS were significantly higher in G1 (p<0.001); there was a significant improvement at IPSS, S-IPSS, QoL score, Qmax, and PVR for all groups after surgery. Only preoperative S-IPSS was found to have significant effect on postoperative SS (p<0.001). There was a significant difference between G1A and G1B but no significant difference between G2A and G2B in terms of SS at postoperatively. In addition to this, prostatic volume was found smaller than non-symptomatic patients in de novo SS patients. Conclusion: TURP provides significant improvement in both storage and voiding symptoms. The predictive value of the preoperative S-IPSS on postop SS is significant. These results suggest that 5 mg solifenacin succinate treatment in the early postoperative period may be beneficial for patients with high preoperative SS and may not be beneficial in others. Small prostatic volume may bode ill for postoperative SS in the patients with de novo SS.en_US
dc.identifier.doi10.1590/S1677-5538.IBJU.2019.0227
dc.identifier.endpage584en_US
dc.identifier.issn1677-5538
dc.identifier.issn1677-6119
dc.identifier.issue4en_US
dc.identifier.pmid32374123en_US
dc.identifier.scopus2-s2.0-85084328594en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage575en_US
dc.identifier.urihttps://doi.org/10.1590/S1677-5538.IBJU.2019.0227
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24387
dc.identifier.volume46en_US
dc.identifier.wosWOS:000530107500012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBrazilian Soc Urolen_US
dc.relation.ispartofInternational Braz J Urolen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTransurethral Resection Of Prostateen_US
dc.subjectRisk Factorsen_US
dc.subjectSolifenacin Succinateen_US
dc.subjectDetrusor Instabilityen_US
dc.subjectFollow-Upen_US
dc.subjectMenen_US
dc.subjectDysfunctionen_US
dc.subjectImprovementen_US
dc.subjectPredictorsen_US
dc.subjectSurgeryen_US
dc.titleThe relation between the storage symptoms before and after transurethral resection of the prostate, analysis of the risk factors and the prevention of the symptoms with solifenacinen_US
dc.typeArticleen_US

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