Effects of a Nociceptin Receptor Antagonist on Experimentally Induced Scratching Behavior in Mice

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dc.authoridGunduz, Ozgur/0000-0002-2470-3021
dc.authoridUlugol, Ahmet/0000-0003-4643-1124
dc.authorwosidGÜNDÜZ, Özgür/AAH-8717-2019
dc.authorwosidGunduz, Ozgur/A-2351-2016
dc.authorwosidUlugol, Ahmet/V-9665-2019
dc.contributor.authorAydemir, K. Duvan
dc.contributor.authorGunduz, O.
dc.contributor.authorUlugol, A.
dc.date.accessioned2024-06-12T11:13:04Z
dc.date.available2024-06-12T11:13:04Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractItch and pain are two distressing sensations sharing a lot in common. In addition to the periphery, the central nervous system is proposed as a therapeutic target for the development of antipruritic drugs. The contribution of the most recently discovered opioid peptide, nociceptin/orphanin FQ (N/OFQ) and its receptor (NOP) in pain transmission is controversial. It seems to be pronociceptive when given supraspinally, but elicits an antinociceptive action when injected spinally. Here, we examined whether the N/OFQ system plays a role in experimentally induced pruritus. Scratching behavior was produced by intradermal administration of serotonin (50 mu g/50 mu l/mouse) or nociceptin (30 nmol/50 mu l/mouse) to Balb/c mice. JTC-801 (1, 3 or 10 mg/kg, i.p.), a NOP receptor antagonist, attenuated both serotonin- and nociceptin-induced scratches. When given intradermally, JTC-801 (100 nmol) significantly reduced serotonin-induced but not nociceptin-induced scratches. We propose that antagonizing NOP receptors either systemically or localy may be a novel approach in the development of antipruritic agents.en_US
dc.identifier.doi10.1007/s11062-017-9641-y
dc.identifier.endpage134en_US
dc.identifier.issn0090-2977
dc.identifier.issn1573-9007
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85027138334en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage130en_US
dc.identifier.urihttps://doi.org/10.1007/s11062-017-9641-y
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23395
dc.identifier.volume49en_US
dc.identifier.wosWOS:000407746000005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofNeurophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPruritusen_US
dc.subjectScratchingen_US
dc.subjectSerotoninen_US
dc.subjectNociceptinen_US
dc.subjectNOP Receptorsen_US
dc.subjectJTC-801en_US
dc.subjectNeural Circuitsen_US
dc.subjectOrl1 Receptoren_US
dc.subjectChronic Painen_US
dc.subjectFqen_US
dc.subjectItchen_US
dc.subjectResponsesen_US
dc.subjectInflammationen_US
dc.subjectParacetamolen_US
dc.subjectInjectionsen_US
dc.subjectCapsaicinen_US
dc.titleEffects of a Nociceptin Receptor Antagonist on Experimentally Induced Scratching Behavior in Miceen_US
dc.typeArticleen_US

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