Analgesic effects of rofecoxib in ear-nose-throat surgery

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dc.contributor.authorTuran, A
dc.contributor.authorEmet, S
dc.contributor.authorKaramanlioglu, B
dc.contributor.authorMemis, D
dc.contributor.authorTuran, N
dc.contributor.authorPamukcu, Z
dc.date.accessioned2024-06-12T11:18:42Z
dc.date.available2024-06-12T11:18:42Z
dc.date.issued2002
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIn this study we evaluated the analgesic efficacy and the opioid-sparing effect of rofecoxib in ear-nose-throat surgery patients. Patients undergoing nasal septal or sinus surgery were randomized to receive either oral placebo or rofecoxib 50 mg 1 h before surgery. All patients received propofol 0.8 mg/kg, fentanyl 1 mug/kg, and local anesthesia at the operative site. Sedation was maintained by a continuous infusion of propofol adjusted to maintain sedation at a 2-3 level on the Ramsey scale. Additional fentanyl 0.5-1 mug/kg was administered at the patient's request or if the verbal rating scale score was >4. Patient sedation and pain scores were obtained at 5, 15, 30 45, and 60 min during surgery and 30 min and 2, 4, 6, 12, and 24 h after completion of the procedure. During the postoperative period, diclofenac 75 mg IM was administered for analgesia at the patient's request or if the visual analog scale (VAS) rating for pain was more than 4. VAS pain scores, intraoperative fentanyl, and postoperative diclofenac requirements were significantly smaller in the rofecoxib group compared with the placebo group (P < 0.001). The times to first analgesic request were also significantly less in the rofecoxib group. We conclude that the preoperative administration of oral rofecoxib provided a significant analgesic benefit and decreased the need for opioids in patients undergoing nasal septal and nasal sinus surgery.en_US
dc.identifier.doi10.1097/00000539-200211000-00039
dc.identifier.endpage1311en_US
dc.identifier.issn0003-2999
dc.identifier.issue5en_US
dc.identifier.pmid12401617en_US
dc.identifier.scopus2-s2.0-0036830296en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1308en_US
dc.identifier.urihttps://doi.org/10.1097/00000539-200211000-00039
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24925
dc.identifier.volume95en_US
dc.identifier.wosWOS:000178912600039en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAnesthesia And Analgesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDental Painen_US
dc.subjectCelecoxiben_US
dc.subjectCox-2en_US
dc.titleAnalgesic effects of rofecoxib in ear-nose-throat surgeryen_US
dc.typeArticleen_US

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