Assessment of Tc-99m sestamibi tumor tissue uptake under the influence of increased arterial oxygen saturation

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dc.authoridCermik, Tevfik Fikret/0000-0001-7622-7277;
dc.authorwosidCermik, Tevfik Fikret/A-9694-2018
dc.authorwosid, osman/HRD-6024-2023
dc.authorwosid, Osman/AGR-7980-2022
dc.contributor.authorCermik, TF
dc.contributor.authorAltiay, G
dc.contributor.authorFirat, MF
dc.contributor.authorHatipoglu, ON
dc.contributor.authorBerkarda, S
dc.date.accessioned2024-06-12T11:16:03Z
dc.date.available2024-06-12T11:16:03Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study is to investigate the potential effect of increased arterial saturation of oxygen in the magnitude of technetium-99m-hexakis-isobutyl-isonitrile ((99)mTc-MIBI) uptake in tumor tissue and to compare the results with those of conventional Tc-99m-MIBI tumor imaging in the same patient with lung cancer. A total of 26 lung cancer patients underwent initial SPECT (I-SPECT) and after oxygen inhalation SPECT (O-2-SPECT). The early (ER) and delayed ratios (DR) Of O-2-SPECT mean +/- S.D. were significantly higher than those of I-SPECT mean +/- S.D. (2.07 +/- 0.57 vs. 1.90 +/- 0.48 and 2.02 +/- 0.45 vs. 1.83 +/- 0.39, respectively). There are increased rates for the relative tumor uptake of Tc-99m-MIBI by 9% for ER and 10% for DR on the O-2-SPECT compared to I-SPECT. We found that 99mTc-MIBI uptake increased significantly in the tumor tissue with O-2-SPECT compared to I-SPECT. In conclusion, 99mTc-MIBI scintigraphy is one of the main methods for differentiating viable and nonviable tissue fractions in tumors. We consider that 99mTc-MIBI uptake increase after oxygen inhalation is an indicator of positive acute cellular response of the tumor tissue to the rising tissue oxygen level. (c) 2005 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.nucmedbio.2004.12.003
dc.identifier.endpage170en_US
dc.identifier.issn0969-8051
dc.identifier.issue2en_US
dc.identifier.pmid15721762en_US
dc.identifier.scopus2-s2.0-13844305874en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage165en_US
dc.identifier.urihttps://doi.org/10.1016/j.nucmedbio.2004.12.003
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24177
dc.identifier.volume32en_US
dc.identifier.wosWOS:000227689100008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofNuclear Medicine And Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTc-99m Sestamibien_US
dc.subjectOxygenen_US
dc.subjectHypoxiaen_US
dc.subjectLung Canceren_US
dc.subjectLung-Canceren_US
dc.subjectP-Glycoproteinen_US
dc.subjectBreast-Canceren_US
dc.subjectChemotherapeutic Responseen_US
dc.subjectFluorodeoxyglucose Uptakeen_US
dc.subjectIntratumoral Distributionen_US
dc.subjectMultidrug-Resistanceen_US
dc.subjectCell-Linesen_US
dc.subjectHypoxiaen_US
dc.subjectTechnetium-99m-Sestamibien_US
dc.titleAssessment of Tc-99m sestamibi tumor tissue uptake under the influence of increased arterial oxygen saturationen_US
dc.typeArticleen_US

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