Oral nifedipine maintenance therapy after acute intravenous tocolysis in preterm labor

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dc.authorwosidSAYIN, N. CENK/A-5801-2018
dc.contributor.authorSayin, NC
dc.contributor.authorVarol, FG
dc.contributor.authorBalkanli-Kaplan, P
dc.contributor.authorSayin, M
dc.date.accessioned2024-06-12T11:08:01Z
dc.date.available2024-06-12T11:08:01Z
dc.date.issued2004
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAims: Our aim was to evaluate the efficacy of maintenance oral nifedipine in pregnant women initially treated with intravenous ritodrine plus verapamil for preterm labor. Methods: The study included 73 patients with preterm labor with intact membranes. Patients were randomized to receive either maintenance oral nifedipine therapy (n=37) administered 20 mg every six hours or no treatment (controls, n=36) after discontinuation of acute intravenous tocolysis. Results: Compared to the control group, the mean +/- SD time gained from initiation of maintenance therapy to delivery (26.65 +/- 18.89 vs. 16.14 +/- 12.91 days, p = 0.007) and the gestational age at delivery (37.03 +/- 2.06 vs. 35.1 +/- 3 weeks, p = 0.003) were higher in the nifedipine maintenance therapy group. The proportion of patients who required one or more courses of subsequent intravenous therapy and perinatal outcomes were similar in the maintenance therapy and control groups. Conclusions: The gestational age and time gained from initiation of maintenance therapy to delivery were longer in women receiving oral maintenance tocolysis with nifedipine. However, maintenance therapy did not decrease the recurrence of preterm labor episodes or improve perinatal outcomes.en_US
dc.identifier.doi10.1515/JPM.2004.041
dc.identifier.endpage224en_US
dc.identifier.issn0300-5577
dc.identifier.issue3en_US
dc.identifier.pmid15188794en_US
dc.identifier.scopus2-s2.0-2942535972en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage220en_US
dc.identifier.urihttps://doi.org/10.1515/JPM.2004.041
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22276
dc.identifier.volume32en_US
dc.identifier.wosWOS:000221759800004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter & Coen_US
dc.relation.ispartofJournal Of Perinatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMaintenance Therapyen_US
dc.subjectNifedipineen_US
dc.subjectPretermen_US
dc.subjectCalcium-Channel Blockersen_US
dc.subjectDouble-Blinden_US
dc.subjectTrialen_US
dc.subjectPreventionen_US
dc.subjectEfficacyen_US
dc.subjectTerbutalineen_US
dc.subjectDeliveryen_US
dc.subjectAgentsen_US
dc.subjectBirthen_US
dc.titleOral nifedipine maintenance therapy after acute intravenous tocolysis in preterm laboren_US
dc.typeArticleen_US

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