Immunohistochemical investigation of caspase-3 in neuronal apoptosis after experimental closed head trauma

Basit Öğe Kaydı
dc.authorscopusid24436194200
dc.authorscopusid7006356462
dc.authorscopusid55135463200
dc.authorscopusid55135930200
dc.contributor.authorAktaş C.
dc.contributor.authorKanter M.
dc.contributor.authorUzun D.
dc.contributor.authorFidanol Z.
dc.date.accessioned2024-06-12T10:26:38Z
dc.date.available2024-06-12T10:26:38Z
dc.date.issued2011
dc.description.abstractThe aim of this study was to investigate the caspase-3 activity in neuronal apoptosis after experimental closed head trauma model in rats. Twenty adult male rats were randomly divided into two groups: control and trauma groups. In trauma group, a cranial impact was delivered to the skull from a height of 7 cm at a point just in front of the coronal suture and over the right hemisphere. Rats were sacrificed at 12 hours after the onset of injury. Brain tissues were removed for histopathological investigation. In the trauma group, the neurons became extensively dark and degenerated into picnotic nuclei. The number of apoptotic neurons in frontal cortex tissue of trauma group was significantly more than control groups. In conclusion, the caspase 3 immunopositivity was increased in degenerating neurons of the frontal cortex tissue following trauma. The present results indicate that closed head trauma caused degenerative changes and increased caspase 3 immonupositivity in neurons. © 2011 OMU All rights reserved.en_US
dc.identifier.doi10.5835/jecm.omu.28.03.002
dc.identifier.endpage102en_US
dc.identifier.issn1300-2996
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84858815361en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage99en_US
dc.identifier.urihttps://doi.org/10.5835/jecm.omu.28.03.002
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16943
dc.identifier.volume28en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Experimental and Clinical Medicine (Turkey)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApoptosis; Brain Tissue; Caspase-3; Closed Head Trauma; Immunohistochemistry; Raten_US
dc.titleImmunohistochemical investigation of caspase-3 in neuronal apoptosis after experimental closed head traumaen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu