A low prevalence of purified protein derivative test positivity in Turkish patients with rheumatoid arthritis. Association with clinical features and HRCT findings
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Tarih
2007
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Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objectives: In this study, we aimed to evaluate the frequency of purified protein derivative (PPD) skin test positivity and associated clinical features in RA patients. Materials and methods: We included 94 (80 F, 14 M, mean age: 55.8) consecutive RA patients with a disease duration of 8.7 years. PPD test was performed in all RA patients; clinical features were recorded down; chest x-ray, pulmonary function tests and HRCT were available in all cases. As the control group, we included data of 21 SLE, 44 AS, 27 OA, 16 gouty arthritis and 18 vasculitis patients. Results: The frequencies of PPD positivity in RA (29.8%) and SLE (19%) patients were lower than in patients with AS (65.9%), gouty arthritis (68.8%) and OA (63%) (all p values < 0.01). PPD positive RA patients were more frequently smokers (p = 0.005) and had a higher rate of RF seropositivity (p = 0.04) than PPD-negatives. PPD was less frequently positive in erosive RA disease (p = 0.033). Chest x-rays and HRCT abnormalities were detected in 41.8% and 62.7% of RA patients, respectively. Frequencies of chest x-ray and HRCT abnormalities in PPD-positive and PPD-negative patients were not different from each other (p > 0.05). Conclusion: In our country in which tuberculosis is relatively frequent -contrary to the situation in AS patients- we observed a lower frequency of PPD positivity in RA and SLE patients compared to patients with other rheumatic diseases. We did not find any relationship between PPD positivity and the frequency of chest x-ray, HRCT abnormalities. © Copyright Clinical and Experimental Rheumatology 2007.
Açıklama
Anahtar Kelimeler
Chest X-Ray; High-Resolution Computerized Tomography; Purified Protein Derivative (Ppd) Test; Rheumatoid Arthritis; Tuberculosis, Antimalarial Agent; Disease Modifying Antirheumatic Drug; Leflunomide; Methotrexate; Rheumatoid Factor; Salazosulfapyridine; Steroid; Adult; Aged; Ankylosing Spondylitis; Article; Bone Erosion; Clinical Feature; Controlled Study; Disease Association; Disease Duration; Female; Gout; High Resolution Computer Tomography; Human; Lung Function Test; Major Clinical Study; Male; Osteoarthritis; Priority Journal; Rheumatic Disease; Rheumatoid Arthritis; Seroprevalence; Smoking; Systemic Lupus Erythematosus; Thorax Radiography; Tuberculin Test; Tuberculosis; Turkey (Republic); Vasculitis; Computer Assisted Tomography; Immunology; Lung Tuberculosis; Middle Aged; Radiography; Rheumatoid Arthritis; Sensitivity And Specificity; Thorax Radiography; Adult; Aged; Arthritis, Rheumatoid; Female; Humans; Male; Middle Aged; Radiography, Thoracic; Respiratory Function Tests; Sensitivity And Specificity; Tomography, X-Ray Computed; Tuberculin Test; Tuberculosis, Pulmonary; Turkey
Kaynak
Clinical and Experimental Rheumatology
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
25
Sayı
1
