A case of refractory chronic lymphocytic leukaemia with an unusual course

Basit Öğe Kaydı
dc.authoridBaysal, Mehmet/0000-0001-7681-4623
dc.authoridKirkizlar, Onur/0000-0001-7523-8599
dc.authorwosidBaysal, Mehmet/E-9111-2018
dc.authorwosidErtan, Asli/AAE-6201-2021
dc.authorwosidKirkizlar, Onur/W-9594-2018
dc.contributor.authorUmit, Elif G.
dc.contributor.authorBaysal, Mehmet
dc.contributor.authorOzdover, Ali Caner
dc.contributor.authorKirkizlar, Onur
dc.contributor.authorDemir, Ahmet Muzaffer
dc.date.accessioned2024-06-12T11:22:38Z
dc.date.available2024-06-12T11:22:38Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractChronic lymphocytic leukaemia (CLL) is a heterogeneous disease with uncertain course. Treatment should be tailored to the patient's disease as well as the prognostic subgroup. With the increased use of rituximab as well as other selective and non-selective immunomodulatory agents, the incidence of infectious complications and second malignancies has also increased. Progressive multifocal leucoencephalopathy (PML) is a complication of rituximab in HIV-negative patients. A 56-year-old male with CLL had been treated and relapsed four times in 6 years. Rituximab was added to the combination after the second relapse and repeated in the third relapse in combination with bendamustine. In the seventh year of diagnosis, relapse of CLL and an ulcerated tumorous lesion was observed in the left index finger, which progressed in 3 months and was later diagnosed as angiosarcoma. The cancer was treated with local radiotherapy and combination chemotherapy. One year after the last rituximab exposure, progressive muscle weakness developed and polyoma JC virus DNA was observed with increased titres in the cerebrospinal fluid, and the patient was diagnosed as having PML. The patient died 2 months later. Our patient had an unusual course of CLL over 8 years, with relapses, complicated with a secondary malignancy and an infectious complication.en_US
dc.identifier.doi10.4103/0970-258X.303614
dc.identifier.endpage+en_US
dc.identifier.issn0970-258X
dc.identifier.issue6en_US
dc.identifier.pmid33380628en_US
dc.identifier.scopus2-s2.0-85098541718en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage347en_US
dc.identifier.urihttps://doi.org/10.4103/0970-258X.303614
dc.identifier.urihttps://hdl.handle.net/20.500.14551/26007
dc.identifier.volume32en_US
dc.identifier.wosWOS:000599426500006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAll India Inst Medical Sciencesen_US
dc.relation.ispartofNational Medical Journal Of Indiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keywords]en_US
dc.titleA case of refractory chronic lymphocytic leukaemia with an unusual courseen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu