Expression levels of maternal plasma microRNAs in preeclamptic pregnancies

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dc.authoridAYAZ, LOKMAN/0000-0002-2876-055X
dc.authoridAkgor, Utku/0000-0003-1377-2651
dc.authorwosidAYAZ, LOKMAN/K-6716-2013
dc.contributor.authorAkgor, Utku
dc.contributor.authorAyaz, Lokman
dc.contributor.authorCayan, Filiz
dc.date.accessioned2024-06-12T10:56:33Z
dc.date.available2024-06-12T10:56:33Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe present study aimed to identify the differential expression profiles of microRNAs in the plasma between patients with preeclampsia (PE) and healthy pregnancies using quantitative real-time PCR. The expression profiles of 32 miRNAs in maternal plasma from 31 patients with PE and 32 healthy pregnancies were evaluated. The expression levels of eight miRNAs including miR-210, miR-375, miR-197-3p, miR-132-3p, miR-29a-3p, miR-328, miR-24-3p, and miR-218-5p were significantly upregulated and the expression levels of three miRNAs, including miR-302b-3p, miR-191-5p, and miR-17-5p, were significantly downregulated in patients with preeclampsia when compared to healthy pregnant women. In conclusion, we identified 11 miRNAs that may be potential biomarkers for non-invasive diagnosis and a pivotal role in the prediction of PE. Considering the small cohort of patients, further studies with larger samples from different gestational stages are necessary to confirm our findings. IMPACT STATEMENT What is already known on this subject? The alterations in the release pattern of placenta-specific miRNAs detected in maternal serum have been found to be associated with pregnancy-related complications such as preeclampsia (PE). What do the results of this study add? In the present study, the release pattern of seven miRNAs had consistency and two of them had inconsistency with previous researches. Moreover, two novel miRNAs were also defined to demonstrate the interrelationship between PE and miRNAs. What are the implications of these findings for clinical practice and/or future research? The identification of 11 miRNAs that may be potential biomarkers for non-invasive diagnosis and a pivotal role in the prediction of PE. Considering the small cohort of patients, further studies with larger samples from different gestational stages are necessary to confirm our findings.en_US
dc.description.sponsorshipMersin University Scientific Research Fund [BAP-TF CTB (UA) 2013-3 TU]en_US
dc.description.sponsorshipThis study was supported by the Mersin University Scientific Research Fund [Grant No: BAP-TF CTB (UA) 2013-3 TU].en_US
dc.identifier.doi10.1080/01443615.2020.1820465
dc.identifier.endpage914en_US
dc.identifier.issn0144-3615
dc.identifier.issn1364-6893
dc.identifier.issue6en_US
dc.identifier.pmid33228451en_US
dc.identifier.scopus2-s2.0-85096598978en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage910en_US
dc.identifier.urihttps://doi.org/10.1080/01443615.2020.1820465
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19834
dc.identifier.volume41en_US
dc.identifier.wosWOS:000591757500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal Of Obstetrics And Gynaecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCirculating Mirnaen_US
dc.subjectPreeclampsiaen_US
dc.subjectBiomarkeren_US
dc.subjectMaternal Mirnaen_US
dc.subjectPregnancy Complicationsen_US
dc.subjectCirculating Micrornasen_US
dc.subjectHypoxiaen_US
dc.subjectTrophoblastsen_US
dc.subjectInhibitionen_US
dc.subjectPlacentaen_US
dc.subjectInvasionen_US
dc.titleExpression levels of maternal plasma microRNAs in preeclamptic pregnanciesen_US
dc.typeArticleen_US

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