Attenuation of vasospasm by dexmedetomidine after experimental subarachnoidal haemorrhage in rabbits

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dc.authorscopusid12752439300
dc.authorscopusid55960443600
dc.authorscopusid7003600530
dc.authorscopusid14420711400
dc.authorscopusid6603136404
dc.authorscopusid14833921600
dc.contributor.authorEser O.
dc.contributor.authorFidan H.
dc.contributor.authorCoşkun Ö.
dc.contributor.authorEla Y.
dc.contributor.authorSongur A.
dc.contributor.authorCoşar M.
dc.date.accessioned2024-06-12T10:28:34Z
dc.date.available2024-06-12T10:28:34Z
dc.date.issued2008
dc.description.abstractAim: Vasospasm is one of the most important factors that influence the successful treatment of ruptured intracranial aneurysm. We studied if vasospasm following subarachnoidal haemorrhage (SAH) can be alleviated by dexmedetomidine in an animal model. Materials and Methods: Experimental SAH was induced in 12 of 18 New Zealand rabbits by intracisternal injection of autologous blood. Control animals (sham SAH, n = 6) received intracisternal injection of the respective volume of physiological saline solution. Forty eight hours after the operation, rabbits in sham SAH and SAH-alone (n = 6) groups were infused intravenously with 0.9% sodium chloride for 2 h, whereas rabbits in SAH-dexmedetomidine group (n = 6) received intravenous infusion of 5 ?g/kg per h dexmedetomidine for 2 h. All rabbits were sacrificed with penthotal 24 h after infusions. Basilar arteries were isolated and processed for histology. Results: The histological specimens revealed evidence of arterial narrowing and vascular wall thickening in both SAH-alone and SAH-dexmedetomidine groups. The wall thickness of basilar artery significantly increased and lumen diameter significantly reduced in SAH-alone group in comparison with basilar arteries from other groups (P < 0.05). SAH-dexmedetomidine group revealed attenuation of vasospasm formed after 72 h. Conclusions: Our study showed that vasospasm is attenuated by dexmedetomidine administered after vasospasm is formed in a rabbit model. © TÜBİTAK.en_US
dc.identifier.endpage197en_US
dc.identifier.issn1300-0144
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-45749111087en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage191en_US
dc.identifier.trdizinid82706en_US
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/82706
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17311
dc.identifier.volume38en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDexmedetomidine; Subarachnoid Haemorrhage; Vasospasmen_US
dc.subject(+ Mod 2n) Operation; Animal Models; Basilar Artery; Haemorrhage; Intracranial Aneurysms; Intravenous Infusion; New Zealand Rabbits; Physiological Saline Solution; Vascular Walls; Wall Thicknesses; Dexmedetomidine; Sodium Chloride; Thiopental; Animal Experiment; Animal Model; Animal Tissue; Artery Diameter; Artery Occlusion; Article; Basilar Artery; Blood Autotransfusion; Blood Vessel Wall; Controlled Study; Drug Effect; Drug Infusion; Heart Muscle Revascularization; Male; Nonhuman; Rabbit; Subarachnoid Hemorrhage; Vasospasmen_US
dc.titleAttenuation of vasospasm by dexmedetomidine after experimental subarachnoidal haemorrhage in rabbitsen_US
dc.typeArticleen_US

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