Anatomical and Phytochemical Characteristics of Different Parts of Hypericum scabrum L. Extracts, Essential Oils, and Their Antimicrobial Potential

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dc.authoridGoger, Gamze/0000-0003-2978-5385
dc.authoridDemirci, Betul/0000-0003-2343-746X
dc.authoridSytar, Oksana/0000-0003-4219-9292
dc.authoridKARAKAYA, Songul/0000-0002-3268-721X
dc.authorwosidGoger, Gamze/JCE-6911-2023
dc.authorwosidDemirci, Betul/AHA-2298-2022
dc.authorwosidSytar, Oksana/H-4673-2014
dc.contributor.authorErgin, Kubra Nalkiran
dc.contributor.authorKarakaya, Songul
dc.contributor.authorGoeger, Gamze
dc.contributor.authorSytar, Oksana
dc.contributor.authorDemirci, Betul
dc.contributor.authorDuman, Hayri
dc.date.accessioned2024-06-12T10:52:05Z
dc.date.available2024-06-12T10:52:05Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractHypericum (Hypericaceae) is a genus that comprises a high number of species around the world. In this study, the roots, aerial parts, flowers, fruits, and aerial parts with flowers from Hypericum scabrum were macerated separately by methanol and water and then fractionated by different solvents of, such as ethyl acetate, n-hexane, butanol, dichloromethane, aqueous residue sub-extracts, and ethnobotanical use. All the extracts, sub-extracts and essential oils of H. scabrum were investigated for the first time in detail for their antimicrobial, total phenolics, and antioxidant activities. Anatomical structures of the root, stem, leaf, upper and lower leaf surface, stamen, sepal, and petal of H. scabrum were examined. The biochemical layout of essential oils was determined by GC and GC/MS. The antioxidant activity was determined by free radical scavenging activity (by DPPH). Antimicrobial activity was applied against Candida albicans ATCC 10231, Escherichia coli ATCC 8739, Staphylococcus aureus ATCC 6538, Bacillus subtilis ATCC 19659, and C. tropicalis ATCC 750 using microdilution methods. The essentials of the aerial parts, flower, and fruit are characterized by the presence of monoterpene hydrocarbons, whereas roots oil include alkanes. The GC-FID and GC-MS analysis showed that major components of roots, aerial parts, flowers, and fruits oils were undecane (66.1%); alpha-pinene (17.5%), gamma-terpinene (17.4%), and alpha-thujene (16.9%); alpha-pinene (55.6%), alpha-thujene (10.9%), and gamma-terpinene (7.7%); alpha-pinene (85.2%), respectively. The aerial part sub-extracts indicated a greater level of total phenolics and antioxidant potential. The n-hexane sub-extracts (from aerial part, flower, and aerial part with flower) showed the best activity against B. subtilis, with 39.06 mu g/mL MIC value. The presented research work indicates that H. scabrum can be a novel promising resource of natural antioxidant and antimicrobial compounds.en_US
dc.description.sponsorshipResearch Agency of Slovak Republic [313011T81300]en_US
dc.description.sponsorshipThis study was supported by the Research Agency of Slovak Republic within the project OPVaI-VA/DP/2018/No. 313011T813 00 Optimization of phenotyping methods: building a national phenotyping platform.en_US
dc.identifier.doi10.3390/molecules27041228
dc.identifier.issn1420-3049
dc.identifier.issue4en_US
dc.identifier.pmid35209017en_US
dc.identifier.scopus2-s2.0-85124619819en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/molecules27041228
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18588
dc.identifier.volume27en_US
dc.identifier.wosWOS:000761455400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofMoleculesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidanten_US
dc.subjectAntimicrobialen_US
dc.subjectEssential Oilen_US
dc.subjectHypericum Scabrumen_US
dc.subjectA-Pineneen_US
dc.subjectSecretory Canalsen_US
dc.subjectAntioxidant Activitiesen_US
dc.subjectPerforatumen_US
dc.subjectGlandsen_US
dc.subjectAciden_US
dc.subjectSeeden_US
dc.subjectLeafen_US
dc.titleAnatomical and Phytochemical Characteristics of Different Parts of Hypericum scabrum L. Extracts, Essential Oils, and Their Antimicrobial Potentialen_US
dc.typeArticleen_US

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