THE FREQUENCY OF Y CHROMOSOME MICRODELETIONS AND CYTOGENETIC ABNORMALITIES IN CASES WITH MALE INFERTILITY FROM THRACE REGION: SINGLE CENTER EXPERIENCE

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dc.contributor.authorYalcintepe, Sinem
dc.contributor.authorEker, Damla
dc.contributor.authorGurkan, Hakan
dc.date.accessioned2024-06-12T11:17:27Z
dc.date.available2024-06-12T11:17:27Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Genetic factors, including Y chromosome microdeletions, are responsible for about 10% of male infertility cases and are particularly associated with azoospermia or severe oligozoospermia. In our study, it was aimed to determine the frequency of Y chromosome microdeletions in the Thrace region and to provide information about the heterogeneous phenotype in infertile male patients with AZF microdeletion. Material and Method: Chromosome analysis and Y chromosome microdeletion analysis were performed on 446 male patients with non-obstructive azoospermia or oligozoospermia, who applied to the Trakya University Hospital Medical Genetics Department Genetic Diseases Diagnosis Center clinic between the years 2011-2019. Results: Y chromosome microdeletion was detected in 19 (4.26%) of 446 cases. Structural chromosomal anomalies were accompanied in 5 of 19 cases with Y chromosome microdeletions. Three hundred fifty-two cases had no Y chromosome microdeletion, 35 (9.94%) of these cases had Klinefelter syndrome, 1 (0.28%) case had Klinefelter syndrome low grade mosaicism, 3 (0.85%) cases had Robertsonian translocation carriage, and 1 (0.28%) had Reciprocal translocation carriage. Conclusion: Y chromosome microdeletion screening in non-obstructive azoospermic or oligosoospermic infertile male patients has prognostic value and affects clinical prognosis. The results of our study support the proposal to perform Y chromosome microdeletion analysis before microTESE in azoospermic or oli-gosoospermic infertile male patients as reported in the literature.en_US
dc.identifier.doi10.26650/IUITFD.2020.0017
dc.identifier.endpage33en_US
dc.identifier.issn1305-6441
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85130381120en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage27en_US
dc.identifier.trdizinid408428en_US
dc.identifier.urihttps://doi.org/10.26650/IUITFD.2020.0017
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/408428
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24697
dc.identifier.volume84en_US
dc.identifier.wosWOS:000629740900004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isotren_US
dc.publisherIstanbul Univ, Fac Medicine, Publ Offen_US
dc.relation.ispartofJournal Of Istanbul Faculty Of Medicine-Istanbul Tip Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectY Microdeletionen_US
dc.subjectMale Infertilityen_US
dc.subjectChromosome Anomalyen_US
dc.subjectAzoospermiaen_US
dc.subjectOligospermiaen_US
dc.subjectNonobstructive Azoospermiaen_US
dc.subjectMenen_US
dc.subjectOligozoospermiaen_US
dc.subjectTranslocationen_US
dc.subjectDeletionen_US
dc.subjectSpermen_US
dc.subjectAzfaen_US
dc.titleTHE FREQUENCY OF Y CHROMOSOME MICRODELETIONS AND CYTOGENETIC ABNORMALITIES IN CASES WITH MALE INFERTILITY FROM THRACE REGION: SINGLE CENTER EXPERIENCEen_US
dc.typeArticleen_US

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