Prognostic factors of patients who received chemotherapy after cranial irradiation for non-small cell lung cancer with brain metastases: A retrospective analysis of multicenter study (Anatolian Society of Medical Oncology)

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dc.authoridOdabas, Hatice/0000-0002-5757-4705
dc.authoridElkıran, Emin Tamer/0000-0001-6681-7249
dc.authoridTanriverdi, Ozgur/0000-0002-0598-7284
dc.authoridduran, Ayse Ocak/0000-0002-1703-726X
dc.authoridOzturk, Banu/0000-0003-0290-8787
dc.authoridCihan, Şener/0000-0002-3960-4982
dc.authoridCihan, Şener/0000-0002-3594-3661
dc.authorwosidOdabas, Hatice/HOH-1716-2023
dc.authorwosidElkıran, Emin Tamer/ABI-8192-2020
dc.authorwosidTanriverdi, Ozgur/M-2172-2015
dc.authorwosidmenekşe, serkan/HNP-3265-2023
dc.authorwosidduran, Ayse Ocak/ABA-7090-2021
dc.authorwosidTastekin, Didem/AAZ-7289-2020
dc.authorwosidOzturk, Banu/AAD-4358-2019
dc.contributor.authorInal, Ali
dc.contributor.authorKodaz, Hilmi
dc.contributor.authorOdabas, Hatice
dc.contributor.authorDuran, Ayse Ocak
dc.contributor.authorSeker, Mehmet Metin
dc.contributor.authorInanc, Mevlide
dc.contributor.authorElkiran, Emin Tamer
dc.date.accessioned2024-06-12T10:55:09Z
dc.date.available2024-06-12T10:55:09Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose: Almost half of all patients diagnosed with non-small cell lung cancer (NSCLC) have distant metastases at presentation. One-third of patients with NSCLC will have brain metastases. Without effective treatment, the median survival is only 1 month. However, it is difficult to treat brain metastases with systemic chemotherapy since the agents have difficulty crossing the blood-brain barrier. Therefore, it is important to estimate the patient's survival prognosis. The aim of this study was to analyze prognostic factors for survival in Turkish patients who received chemotherapy after cranial irradiation for NSCLC with brain metastases. Methods: We retrospectively reviewed 698 patients with brain metastases resulting from NSCLC. Ten potential prognostic variables were chosen for analysis. Univariate and multivariate analyses were conducted to identify prognostic factors associated with overall survival (OS). Results: Among the 10 variables for univariate analysis, six were identified to have prognostic significance; these included sex, smoking history, histology, number of brain metastases, extracranial metastases, and neurosurgical resection. Multivariate analysis by the Cox proportional hazard model showed that a smoking history, extracranial metastases, and neurosurgical resection were independent negative prognostic factors for OS. Conclusion: Smoking history, extracranial metastases, and neurosurgical resection were considered independent negative prognostic factors for OS. These findings may facilitate pretreatment prediction of survival and can be used for selecting patients for more appropriate treatment options.en_US
dc.identifier.doi10.4103/0973-1482.176417
dc.identifier.endpage582en_US
dc.identifier.issn0973-1482
dc.identifier.issn1998-4138
dc.identifier.issue3en_US
dc.identifier.pmid29893321en_US
dc.identifier.scopus2-s2.0-85048665590en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage578en_US
dc.identifier.urihttps://doi.org/10.4103/0973-1482.176417
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19298
dc.identifier.volume14en_US
dc.identifier.wosWOS:000435353000019en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMedknow Publications & Media Pvt Ltden_US
dc.relation.ispartofJournal Of Cancer Research And Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBrain Metastasesen_US
dc.subjectNon-Small Cell Lung Canceren_US
dc.subjectPrognostic Factorsen_US
dc.subjectTyrosine Kinase Inhibitorsen_US
dc.subjectPhase-Ii-Trialen_US
dc.subjectRadical Treatmenten_US
dc.subjectNever-Smokersen_US
dc.subjectSurvivalen_US
dc.subjectAdenocarcinomaen_US
dc.subjectManagementen_US
dc.subjectTherapyen_US
dc.subjectRadiotherapyen_US
dc.subjectGefitiniben_US
dc.titlePrognostic factors of patients who received chemotherapy after cranial irradiation for non-small cell lung cancer with brain metastases: A retrospective analysis of multicenter study (Anatolian Society of Medical Oncology)en_US
dc.typeArticleen_US

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