The efficiency of CAPE on retardation of hepatic fibrosis in biliary obstructed rats

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dc.contributor.authorTomur, Ahmet
dc.contributor.authorKanter, Mehmet
dc.contributor.authorGurel, Ahmet
dc.contributor.authorErboga, Mustafa
dc.date.accessioned2024-06-12T10:55:41Z
dc.date.available2024-06-12T10:55:41Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the possible protective effects of caffeic acid phenethyl ester (CAPE) against cholestatic oxidative stress and liver damage in the common bile duct ligated rats. A total of 18 male Sprague-Dawley rats were divided into three groups: control, bile duct ligation (BDL) and BDL + received CAPE; each group contain 6 animals. The rats in CAPE treated groups were given CAPE (10 mu mol/kg) once a day intraperitoneally (i.p) for 2 weeks starting just after BDL operation. The changes demonstrating the bile duct proliferation and fibrosis in expanded portal tracts include the extension of proliferated bile ducts into lobules, inflammatory cell infiltration into the widened portal areas were observed in BDL group. Treatment of BDL with CAPE attenuated alterations in liver histology. The proliferating cell nuclear antigen and the activity of TUNEL in the BDL were observed to be reduced with the QE treatment. The application of BDL clearly increased the tissue hydroxyproline (HP) content, malondialdehyde (MDA) levels and decreased the antioxidant enzyme (superoxide dismutase (SOD), glutathione peroxidase (GPx)) activities. CAPE treatment significantly decreased the elevated tissue HP content, and MDA levels and raised the reduced of SOD, and GPx enzymes in the tissues. The data indicate that CAPE attenuates BDL-induced cholestatic liver injury, bile duct proliferation, and fibrosis. The hepatoprotective effect of CAPE is associated with antioxidative potential.en_US
dc.identifier.doi10.1007/s10735-011-9350-6
dc.identifier.endpage458en_US
dc.identifier.issn1567-2379
dc.identifier.issn1567-2387
dc.identifier.issue5en_US
dc.identifier.pmid21822612en_US
dc.identifier.scopus2-s2.0-80052697859en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage451en_US
dc.identifier.urihttps://doi.org/10.1007/s10735-011-9350-6
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19494
dc.identifier.volume42en_US
dc.identifier.wosWOS:000294824500009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Molecular Histologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCAPEen_US
dc.subjectImmunohistochemistryen_US
dc.subjectTUNELen_US
dc.subjectLiveren_US
dc.subjectBile Duct Ligationen_US
dc.subjectAcid Phenethyl Esteren_US
dc.subjectDamageen_US
dc.subjectInjuryen_US
dc.subjectInhibitorsen_US
dc.subjectApoptosisen_US
dc.subjectCirrhosisen_US
dc.titleThe efficiency of CAPE on retardation of hepatic fibrosis in biliary obstructed ratsen_US
dc.typeArticleen_US

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