The effects of N-acetylcysteine on intestinal ischemia/reperfusion injury in rats

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dc.authoridAydın, Seval/0000-0001-6873-5730
dc.authoridUzun, Hafize/0000-0002-1347-8498
dc.authoridUmit, Hasan/0000-0002-3651-4180
dc.authorwosidAydın, Seval/D-5026-2019
dc.authorwosidaydın, seval/AAD-3579-2021
dc.authorwosidUmit, Hasan/T-6236-2019
dc.authorwosidUzun, Hafize/D-4811-2019
dc.contributor.authorAyvaz, Suleyman
dc.contributor.authorAksu, Burhan
dc.contributor.authorInan, Mustafa
dc.contributor.authorUzun, Hafize
dc.contributor.authorAydin, Seval
dc.contributor.authorBilgi, Selcuk
dc.contributor.authorUmit, Hasan C.
dc.date.accessioned2024-06-12T11:19:48Z
dc.date.available2024-06-12T11:19:48Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: To evaluate the effects of N-acetylcysteine (NAC) on the injury of intestinal ischemia-reperfusion. Methods: Forty-eight Wistar-Albino rats were divided into 6 groups: as control, ischemia, ischemia-reperfusion, ischemia + N-acetylcysteine, ischemia-reperfusion + N-acerylcysteine (IRN), and reperfusion + N-acetylcysteine (RN). Histopathologic examination was performed to all groups. In the tissue and plasma, and erythrocyte samples, malondialdehyde, superoxide dismutase, glutathione, and nitric oxide (NO) levels were evaluated. The present study was carried out in Trakya and Istanbul University, Edirne, Turkey between December 2002 and July 2003. Results: The most severe histopathological damage was seen in the intestinal ischemia-reperfusion group, and this damage was observed to be reduced by NAC administration. Lowest plasma malondialdehyde levels were observed in RN group. The tissue glutathione levels were found to be higher in RN group than those in IRN group. Conclusion: It was found that administration of NAC has important effects on the injury of intestinal ischemia, as well as, reperfusion in rats. N-acerylcysteine administration causes an improvement in the histopathologic findings of ischemia/reperfusion damages. The N-acerylcysteine treatment protects the antioxidant enzymes in the tissue, plasma, and the erythrocytes, which are crucially important in the intestinal schemia/reperfusion injury in rats.en_US
dc.identifier.endpage29en_US
dc.identifier.issn0379-5284
dc.identifier.issue1en_US
dc.identifier.pmid19139768en_US
dc.identifier.scopus2-s2.0-62849084588en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage24en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25348
dc.identifier.volume30en_US
dc.identifier.wosWOS:000263497800003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSaudi Med Jen_US
dc.relation.ispartofSaudi Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectReperfusion Injuryen_US
dc.subjectIschemiaen_US
dc.subjectMechanismsen_US
dc.subjectGlutathioneen_US
dc.subjectDamageen_US
dc.titleThe effects of N-acetylcysteine on intestinal ischemia/reperfusion injury in ratsen_US
dc.typeArticleen_US

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