Trinitrobenzensülfonik asit koliti oluşturulan ratlarda L-karnitinin epitel hasarına etkisi
Küçük Resim Yok
Tarih
2008
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Trakya Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Çalışmamızda Trinitrobenzensulfonikasit ile deneysel kolit oluşturulan ratlarda, intraperitoneal L-karnitinin antiinflamatuvar sürece etkisini, makroskopik, mikroskopik ve biyokimyasal olarak araştırdık.Kırk adet erkek Wister Albino cinsi rat 10'arlı 4 gruba ayrıldı. 1. grup kontrol grubu, 2. grup hasta grubu, 3. grup kolit oluşumunu takiben L-karnitin tedavisi verilen grup, 4. grup L-karnitin tedavisinden 24 saat sonra kolit oluşturulan grup.Makroskopik olarak; kolit oluşturulan gruplar arasında istatistiksel yönden anlamlı bir fark saptanmadı (p>0.05).Mikroskopik yönden; gruplar arasında istatistiksel yönden anlamlı bir fark saptanmadı (p>0.05).Hastalıklı kontrol grupta (Grup B) Süperoksit dismutaz, Katalaz ve Glutatyon düzeyleri belirgin olarak azaldığı, kolit oluşturulup L-karnitin tedavisi verilen gruplarda (grup C, D) ise Süperoksit dismutaz, Katalaz ve Glutatyon düzeylerinin istatiksel yönden anlamlı olarak yükseldiği görüldü (p<0.05).Malondialdehit düzeyi; Hastalıklı kontrol grubunda (Grup B) belirgin olarak yükseldiği, L-karnitin tedavisi verilen gruplarda (Grup C, D) ise anlamlı olarak gerilediği saptandı (p<0.05).Miyeloperoksidaz düzeyi; hastalıklı kontrol grubunda (Grup B) yükseldiği, L-karnitin tedavisi verilen gruplarda ise (Grup C, D) istatistiksel açıdan anlamlı olarak gerilediği saptandı (p<0.05).Sonuç olarak; L-karnitin'in Ülseratif Kolit tedavisinde antioksidan ve antiinflamatuvar etkileri nedeni ile destekleyici tedavide kullanılabileceğini düşünmekteyiz.Anahtar kelimeler: Ülseratif kolit, L-karnitin, antioksidan, antiinflamatuvar.
In our study, we investigated the effects of intraperitoneally administered L-carnitene on the inflammatory process in rats with experimental colitis with trinitrobenzensulphonic acid, by macroscopic, mikroscopic and biochemical methods.Forty Wister Albino rats are included in this study and divided into four groups. The first group was stated as the control group (Group A) while the second group as the patient control group (B), the third group as treated with L-carnitene after the development of colitis (Group C) and the fourth group as developing colitis 24 hours after the treatment with L-carnitene (Group D).No statistically significant difference was found between the colitis groups with macroscopic methods (p>0.05). Likewise, no statistically significant difference was found between the groups with microscopic methods.The levels of superoxyde dismutase, katalase and glutathione were found to be decreased significantly in the patient control group, while the levels were found to be increased significantly in groups (Groups C and D) treated with L-carnitene (p<0.05).The levels of Malondialdehyde were found to be increased in the patient control group (Grop B), while the levels were found to be decreased in groups treated with L-carnitene (Group C and D) (p<0.05).The levels of myeloperoxidase were found to be increased in patient control group (Grup B) while significantly decreased in groups treated with L-carnitene (Group C and D) (p<0.05).As a result, we suggest the use of L-carnitene as a supportive therapy in Ulcerative Colitis due to its antioxidant and antiinflammatory effects.Key Words: Ulcerative colitis, L-carnitene, antioxidant, antiinflammatory
In our study, we investigated the effects of intraperitoneally administered L-carnitene on the inflammatory process in rats with experimental colitis with trinitrobenzensulphonic acid, by macroscopic, mikroscopic and biochemical methods.Forty Wister Albino rats are included in this study and divided into four groups. The first group was stated as the control group (Group A) while the second group as the patient control group (B), the third group as treated with L-carnitene after the development of colitis (Group C) and the fourth group as developing colitis 24 hours after the treatment with L-carnitene (Group D).No statistically significant difference was found between the colitis groups with macroscopic methods (p>0.05). Likewise, no statistically significant difference was found between the groups with microscopic methods.The levels of superoxyde dismutase, katalase and glutathione were found to be decreased significantly in the patient control group, while the levels were found to be increased significantly in groups (Groups C and D) treated with L-carnitene (p<0.05).The levels of Malondialdehyde were found to be increased in the patient control group (Grop B), while the levels were found to be decreased in groups treated with L-carnitene (Group C and D) (p<0.05).The levels of myeloperoxidase were found to be increased in patient control group (Grup B) while significantly decreased in groups treated with L-carnitene (Group C and D) (p<0.05).As a result, we suggest the use of L-carnitene as a supportive therapy in Ulcerative Colitis due to its antioxidant and antiinflammatory effects.Key Words: Ulcerative colitis, L-carnitene, antioxidant, antiinflammatory
Açıklama
Tıpta Uzmanlık
Anahtar Kelimeler
Gastroenteroloji, Gastroenterology
