Is fondaparinux an effective alternative anticoagulant in patients with heparin-induced thrombocytopenia type II? A case report and review of the literature

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dc.authorscopusid15756259700
dc.authorscopusid14219156500
dc.authorscopusid25226265900
dc.authorscopusid35546856700
dc.authorscopusid6701664192
dc.authorscopusid7004457653
dc.contributor.authorTekgündüz E.
dc.contributor.authorAkpinar S.
dc.contributor.authorÖztürk E.
dc.contributor.authorEmel Pamuk G.
dc.contributor.authorTurgut B.
dc.contributor.authorDemir M.
dc.date.accessioned2024-06-12T10:28:49Z
dc.date.available2024-06-12T10:28:49Z
dc.date.issued2009
dc.description.abstractAlthough rare, heparin-induced thrombocytopenia (HIT) is one of the most feared complications of heparin therapy. It is an antibody-mediated, acquired and transient thrombotic disorder following exposure to heparin. Unfractionated heparin is the standard anticoagulation used in hemodialysis sessions and hemodialysis patients who are continually exposed to heparin are at increased risk for HIT. We report a 75-year-old male patient with acute-on-chronic renal failure who subsequently developed HIT while on hemodialysis. The patient was presented with deep vein thrombosis and successfully treated with fondaparinux. In this report we also review the off-label use of fondaparinux for the treatment and prophylaxis of thrombosis in patients with HIT. As fondaparinux is too small to be recognized by the majority of heparin-reactive antibodies it could be a reasonable alternative anticoagulant for symptomatic HIT patients where licensed drugs like lepirudin and danaparoid are not available. © Medical Journal of Trakya University. Published by Ekin Medical Publishing. All rights reserved.en_US
dc.identifier.endpage172en_US
dc.identifier.issn1301-3149
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-70349147873en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage166en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17442
dc.identifier.volume26en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofTrakya Universitesi Tip Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFondaparinux; Hemodialysis; Heparin-Induced Thrombocytopenia; Thrombosisen_US
dc.subjectEnoxaparin; Fondaparinux; Heparin; Warfarin; Aged; Anticoagulant Therapy; Article; Case Report; Chronic Kidney Failure; Deep Vein Thrombosis; Drug Efficacy; Dyspnea; Extracorporeal Circulation; Hemodialysis; Heparin Induced Thrombocytopenia; Human; International Normalized Ratio; Leg Edema; Low Drug Dose; Male; Tachypnea; Thrombocyte Counten_US
dc.titleIs fondaparinux an effective alternative anticoagulant in patients with heparin-induced thrombocytopenia type II? A case report and review of the literatureen_US
dc.typeArticleen_US

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