Soybean oil prevents peritoneal adhesions without impairing colonic anastomotic healing
Küçük Resim Yok
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aim: Adhesion formation could potentially result in significant morbidity and mortality. In the present study, we investigated the role of soybean oil in the prevention of peritoneal adhesions and its effect on the anastomotic healing process. Patients and Methods: A total of 40 male Wistar Albino rats were randomly assigned to four groups: group A, adhesion induction method; group B, adhesion induction method with administration of soybean oil; group C, colonic anastomosis method; and group D, colonic anastomosis method with administration of soybean oil. Adhesions were scored on postoperative day 7. Anastomotic healing was assessed by determining anastomotic bursting pressure (ABP), tissue hydroxyproline content and the histopathological examination. The serum malondialdehyde (MDA), nitric oxide (NO) and myeloperoxidase (MPO) levels were determined to evaluate cellular response to injury. Results: The difference in mean values between saline-and soybean oil-treated groups, using both the adhesion method and colonic anastomosis method, were statistically significant (P = 0.0003, P = 0.009). Soybean oil administration resulted in no significant difference in terms of ABP and histopathological scores (P = 0.694 and P = 0.246, respectively). Tissue hydroxyproline content was increased significantly with soybean oil administration (P = 0.001). Mean MDA, NO and MPO levels were significantly decreased in the soybean-administered colonic anastomosis group (P = 0.001, P = 0.001, P = 0.002, and respectively). In the soybean-administered adhesion group, mean MDA, NO and MPO levels were lower than in the control group, but the differences were not significant (P = 0.113, P = 0.958, and P = 0.597, respectively). Conclusion: Soybean oil administration intraperitoneally has been shown to prevent adhesion formation effectively without impairing the colonic anastomotic healing process.
Açıklama
Anahtar Kelimeler
Colonic Anastomotic Healing, Intraperitoneal Adhesion, Soybean Oil, Nitric-Oxide Synthase, Surgery, Multicenter, Expression
Kaynak
Surgical Practice
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
19
Sayı
3
