Concepts of Double Hit and Triple Hit Disease in Multiple Myeloma, Entity and Prognostic Significance

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dc.authoridKirkizlar, Onur/0000-0001-7523-8599
dc.authoridBaysal, Mehmet/0000-0001-7681-4623
dc.authoridGürkan, Hakan/0000-0002-8967-6124
dc.authoridatli, emine ikbal/0000-0001-9003-1449
dc.authoridDemirci, Ufuk/0000-0001-6923-1470
dc.authorwosidKirkizlar, Onur/W-9594-2018
dc.authorwosidBaysal, Mehmet/E-9111-2018
dc.authorwosidGürkan, Hakan/AAF-2866-2020
dc.authorwosidatli, emine ikbal/AAN-5060-2020
dc.contributor.authorBaysal, Mehmet
dc.contributor.authorDemirci, Ufuk
dc.contributor.authorUmit, Elif
dc.contributor.authorKirkizlar, Hakki Onur
dc.contributor.authorAtli, Emine Ikbal
dc.contributor.authorGurkan, Hakan
dc.contributor.authorGulsaran, Sedanur Karaman
dc.date.accessioned2024-06-12T11:19:50Z
dc.date.available2024-06-12T11:19:50Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractRisk assessment in newly diagnosed multiple myeloma patients (NDMM) is the first and the most crucial determinant of treatment. With the utilization of FISH analysis as a part of routine practice, high risk Multiple Myeloma (MM) is defined as having at least one of the mutations related with poor prognosis including; t(4;14) t(14;16), t(14;20), del 17p, p53 mutation, gain 1q and del 1p. M-Smart MM risk stratification guideline by Mayo Clinic has proposed a concept similar to high grade lymphomas. Having two of the high risk genetic abnormalities were defined as double hit MM and having any three as triple hit MM. Based on these definitions which may bring a much more clinically relatable understanding in MM prognosis, we aimed to assess our database regarding these two concepts and their probable significance in terms of outcome and prognosis. We retrospectively evaluated 159 newly diagnosed multiple myeloma patients and their clinical course. Among these patients; twenty-four patients have one high risk determinant and also seven and two patients were classified as double hit MM and triple hit MM respectively. Overall survival (OS) of the patients with double hit MM was 6 months, 32.0 months for patients with single high risk abnormality and 57.0 months for patients with no high risk abnormality. Univariate analysis showed that Double Hit and Triple Hit MM is a predictive of low OS. Hazard Ratio of patients with one high risk abnormality was 1.42, double-hit MM patients was 5.55, and triple-hit MM patients was 7.3. Despite the development of novel drugs and their effects of prolonging survival, the treatment has not been individualized. Understanding the biology of each patient as a unique process will be the success of the treatment. As it is known that some MM patients harbor high risk genetic abnormalities according to FISH analysis, we can continue the argument that some patients bring an even higher risk and that can be defined as double or triple hit MM.en_US
dc.identifier.doi10.1038/s41598-020-62885-0
dc.identifier.issn2045-2322
dc.identifier.issue1en_US
dc.identifier.pmid32249811en_US
dc.identifier.scopus2-s2.0-85083022634en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1038/s41598-020-62885-0
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25365
dc.identifier.volume10en_US
dc.identifier.wosWOS:000563473900004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNature Portfolioen_US
dc.relation.ispartofScientific Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRisk-Stratificationen_US
dc.subjectFishen_US
dc.titleConcepts of Double Hit and Triple Hit Disease in Multiple Myeloma, Entity and Prognostic Significanceen_US
dc.typeArticleen_US

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