Effect of delayed radical cystectomy for invasive bladder tumors on lymph node positivity, cancer-specific survival and total survival

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dc.contributor.authorTurk, Hakan
dc.contributor.authorUn, Sitki
dc.contributor.authorCinkaya, Ahmet
dc.contributor.authorKodaz, Hilmi
dc.contributor.authorParvizi, Murtaza
dc.contributor.authorZorlu, Ferruh
dc.date.accessioned2019-06-24T12:32:54Z
dc.date.available2019-06-24T12:32:54Z
dc.date.issued2018
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyasyon Onkolojisi Anabilim Dalıen_US
dc.descriptionKodaz, Hilmi (Trakya Author)en_US
dc.description.abstractIntroduction: Radical cystectomy (RC) is the main treatment option for patients with muscle-invasive bladder cancer (MIBC) and non-muscle-invasive bladder cancer (NMIBC), which carry the highest risk of progression. In this study, we investigated the effect of time from transurethral resection of the bladder (TUR-B) to cystectomy on lymph node positivity, cancer-specific survival and overall survival in patients with MIBC. Methods: The records were reviewed of 530 consecutive patients who had RC and pelvic lymphadenectomy procedures with curative intent performed by selected surgeons between May 2005 and April 2016. Our analysis included only patients with transitional cell carcinoma of the bladder; we excluded 23 patients with other types of tumor histology. Results: Patients who underwent delayed RC were compared with patients who were treated with early RC; both groups were similar in terms of age, gender, T stage, tumor grade, tumor differentiation, lymph node status and metastasis status. However, when both groups were compared for disease-free survival and overall survival, patients of the early-RC group had a greater advantage. Conclusions: The optimal time between the last TUR-B and RC is still controversial. A reasonable time for preoperative preparation can be allowed, but long delays, especially those exceeding 3 months, can lead to unfavorable outcomes in cancer control.en_US
dc.identifier.citationTürk, H., Ün, S., Cinkaya, A., Kodaz, H., Parvizi, M., & Zorlu, F. (2018). Effect of delayed radical cystectomy for invasive bladder tumors on lymph node positivity, cancer-specific survival and total survival. Tumori Journal, 104(6), 434-437.en_US
dc.identifier.doi10.5301/tj.5000626en_US
dc.identifier.endpage437en_US
dc.identifier.issue6en_US
dc.identifier.pmid28665471en_US
dc.identifier.scopus2-s2.0-85063542014en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage434en_US
dc.identifier.urihttps://doi.org/10.5301/tj.5000626
dc.identifier.urihttps://hdl.handle.net/20.500.14551/4185
dc.identifier.volume104en_US
dc.identifier.wosWOS:000454667200022en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb fo Sciencesen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publicatıons Ltd.en_US
dc.relation.ispartofTumori Jen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240608_ID_Qen_US
dc.subjectCancer-Specific Survivalen_US
dc.subjectDisease-Free Survivalen_US
dc.subjectLymph Node Positivityen_US
dc.subjectRadical Cystectomyen_US
dc.subjectTransitional-Cell-Carcinomaen_US
dc.subjectAdjuvant Chemotherapyen_US
dc.subjectUrothelial Carcinomaen_US
dc.subjectMuscle Invasionen_US
dc.subjectEau Guidelinesen_US
dc.subjectDiagnosisen_US
dc.subjectPrognosisen_US
dc.titleEffect of delayed radical cystectomy for invasive bladder tumors on lymph node positivity, cancer-specific survival and total survivalen_US
dc.typeArticleen_US

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