Combination therapy of Nigella sativa and human parathyroid hormone on bone mass, biomechanical behavior and structure in streptozotocin-induced diabetic rats

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dc.authoridKartal, Murat Emre/0000-0003-3896-3438;
dc.authorwosidKartal, Murat Emre/ABA-8196-2021
dc.authorwosidAltan, Mehmet Fatih/AAN-4643-2021
dc.authorwosidDönmez, Senayi/AAB-8905-2020
dc.contributor.authorAltan, Mehmet Fatih
dc.contributor.authorKanter, Mehmet
dc.contributor.authorDonmez, Senayi
dc.contributor.authorKartal, Murat Emre
dc.contributor.authorBuyukbas, Sadik
dc.date.accessioned2024-06-12T11:09:13Z
dc.date.available2024-06-12T11:09:13Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstractExtracts of the seeds of Nigella sativa (NS), an annual herbaceous plant of the Ranunculaceae family, have been used for many years for therapeutic purposes, including their potential anti-diabetic properties. The aim of the present study was to test the hypothesis that combined treatment with NS and human parathyroid hormone (hPTH) is more effective than treatment with NS or hPTH atone in improving bone mass, connectivity, biomechanical behaviour and strength in insulin-dependent diabetic rats. Diabetes was induced by intraperitoneal injection of streptozotocin (STZ) at a single dose of 50mg/kg. The diabetic rats received NS (2 ml/kg/day, i.p.), hPTH (6 mu g/kg/clay, i.p.) or NS and hPTH combined for 4 weeks, starting 8 weeks after STZ injection. The beta-cells of the pancreatic islets of Langerhans were examined by immunohistochemical methods. In addition, bone sections of femora were processed for histomorphometry and biomechanical. analysis. In diabetic rats, the beta-cells were essentially negative for insltin-immunoreactivity. NS treatment (alone or in combination with hPTH) significantly increased the area of insulin immunoreactive beta-cells in diabetic rats; however, hPTH treatment atone only led to a slightly increase in the insulin-immunoreactivity. These results suggest that NS might be used in a similar manner to insulin as a safe and effective therapy for diabetes and might be useful in the treatment of diabetic osteopenia. (c) 2007 Elsevier GmbH. All rights reserved.en_US
dc.identifier.doi10.1016/j.acthis.2007.02.006
dc.identifier.endpage314en_US
dc.identifier.issn0065-1281
dc.identifier.issn1618-0372
dc.identifier.issue4en_US
dc.identifier.pmid17395251en_US
dc.identifier.scopus2-s2.0-34250729777en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage304en_US
dc.identifier.urihttps://doi.org/10.1016/j.acthis.2007.02.006
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22725
dc.identifier.volume109en_US
dc.identifier.wosWOS:000248408100005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Gmbhen_US
dc.relation.ispartofActa Histochemicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNigella Sativaen_US
dc.subjectHuman Parathyroid Hormoneen_US
dc.subjectBone Histomorphometryen_US
dc.subjectPancreatic Beta-Cellsen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectStreptozotocinen_US
dc.subjectRaten_US
dc.subjectBeta-Cell Damageen_US
dc.subjectOxidative Stressen_US
dc.subjectMineral Densityen_US
dc.subjectTrabecular Boneen_US
dc.subjectCortical Boneen_US
dc.subjectOilen_US
dc.subjectOsteoporosisen_US
dc.subjectStrengthen_US
dc.subjectInsulinen_US
dc.subjectWomenen_US
dc.titleCombination therapy of Nigella sativa and human parathyroid hormone on bone mass, biomechanical behavior and structure in streptozotocin-induced diabetic ratsen_US
dc.typeArticleen_US

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