Non-opioid Analgesics and the Endocannabinoid System

Basit Öğe Kaydı
dc.contributor.authorTopuz, Ruhan Deniz
dc.contributor.authorGündüz, Özgür
dc.contributor.authorKaradağ, Çetin Hakan
dc.contributor.authorUlugöl, Ahmet
dc.date.accessioned2021-11-20T10:10:08Z
dc.date.available2021-11-20T10:10:08Z
dc.date.issued2020
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Anabilim Dalıen_US
dc.description.abstractNon-steroidal anti-inflammatory drugs produce antinociceptive effects mainly through peripheral cyclooxygenase inhibition. In opposition to the classical non-steroidal anti-inflammatory drugs, paracetamol and dipyrone exert weak anti-inflammatory activity, their antinociceptive effects appearing to be mostly due to mechanisms other than peripheral cyclooxygenase inhibition. In this review, we classify classical non-steroidal anti-inflammatory drugs, paracetamol and dipyrone as “non-opioid analgesics” and discuss the mechanisms mediating participation of the endocannabinoid system in their antinociceptive effects. Non-opioid analgesics and their metabolites may activate cannabinoid receptors, as well as elevate endocannabinoid levels through different mechanisms: reduction of endocannabinoid degradation via fatty acid amide hydrolase and/or cyclooxygenase-2 inhibition, mobilization of arachidonic acid for the biosynthesis of endocannabinoids due to cyclooxygenase inhibition, inhibition of endocannabinoid cellular uptake directly or through the inhibition of nitric oxide synthase production, and induction of endocannabinoid release.en_US
dc.identifier.doi10.4274/balkanmedj.galenos.2020.2020.6.66en_US
dc.identifier.endpage315en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue6en_US
dc.identifier.pmid32551466en_US
dc.identifier.scopus2-s2.0-85090415637en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage309en_US
dc.identifier.trdizinid418812en_US
dc.identifier.urihttps://doi.org/10.4274/balkanmedj.galenos.2020.2020.6.66
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TkRFNE9ERXlNZz09
dc.identifier.urihttps://hdl.handle.net/20.500.14551/5529
dc.identifier.volume37en_US
dc.identifier.wosWOS:000582143700002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb fo Sciencesen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240608_ID_Qen_US
dc.subject[No Keywords]en_US
dc.titleNon-opioid Analgesics and the Endocannabinoid Systemen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
5529.pdf
Boyut:
466.66 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu
Balkan Medical Journal
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu