Effect of oral gabapentin on postoperative epidural analgesia

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dc.contributor.authorTuran, A
dc.contributor.authorKaya, G
dc.contributor.authorKaramanlioglu, B
dc.contributor.authorPamukçu, Z
dc.contributor.authorApfel, CC
dc.date.accessioned2024-06-12T10:51:36Z
dc.date.available2024-06-12T10:51:36Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground. Gabapentin has been used successfully as a non-opioid analgesic adjuvant for postoperative pain management. We hypothesized that gabapentin might be a useful adjuvant for postoperative analgesia provided with patient-controlled epidural analgesia (PCEA). Methods. Forty patients undergoing lower extremity surgery procedures were randomly assigned to receive (i) placebo capsules (control) or (ii) gabapentin (1.2 g day(-1)) before and for 2 days after surgery. Anaesthetic technique was standardized. Postoperative assessments included verbal rating scale scoring for pain and sedation, PCEA usage, quality of recovery assessment, times of GI function recovery, and patient satisfaction scoring for pain management. Results. Pain scores at 1, 4, 8, 12, and 16 h (P < 0.001), PCEA bolus requirements (n) at 24 [21 (3), 14 (2)], 48 [15 (4), 10 (3)] and 72 [8 (5), 2 (3)] (P < 0.05) and paracetamol (mg) consumption [700 (523), 350 (400)]; P < 0.05), were significantly lower in the gabapentin-treated patients than in the control group. Patient satisfaction with postoperative pain management at 24 h was better in gabapentin-treated patients [85.5 (7.5), 66.5 (15)]; P < 0.001). Gabapentin-treated patients had less motor block when compared with control group. Times of return of bowel function, hospitalization, and resumption of dietary intake were similar in the groups. However, the incidence of dizziness was higher in the gabapentin group (35% vs 5%; P < 0.05). Conclusions. Oral gabapentin (1.2 g day(-1)) as an adjunct to epidural analgesia decreased pain and analgesic consumption. Despite an increased incidence of dizziness it also increased patient satisfaction.en_US
dc.identifier.doi10.1093/bja/aei294
dc.identifier.endpage246en_US
dc.identifier.issn0007-0912
dc.identifier.issn1471-6771
dc.identifier.issue2en_US
dc.identifier.pmid16361302en_US
dc.identifier.scopus2-s2.0-31744446355en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage242en_US
dc.identifier.urihttps://doi.org/10.1093/bja/aei294
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18410
dc.identifier.volume96en_US
dc.identifier.wosWOS:000235306600017en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofBritish Journal Of Anaesthesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnalgesic Techniques, Epiduralen_US
dc.subjectAnalgesic Techniques, Regionalen_US
dc.subjectAnalgesics Non-Opioid, Gabapentinen_US
dc.subjectPain, Postoperativeen_US
dc.subjectPainen_US
dc.subjectMorphineen_US
dc.subjectSurgeryen_US
dc.subjectAnesthesiaen_US
dc.titleEffect of oral gabapentin on postoperative epidural analgesiaen_US
dc.typeArticleen_US

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