Methylation of RAR? is a New Clinical Biomarker for Treatment in Higher-grade Gliomas
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wolters Kluwer Medknow Publications
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: The dysregulation of various pathways and cellular processes contributes to the carcinogenic transition from low-grade gliomas to high-grade gliomas. The altered tumor microenvironment, altered epigenetic state, and high mutation heterogeneity are critical factors in glial tumors. The morphogen retinoic acid (RA) controls the homeostasis, regeneration, and development of the brain. RA receptor (RAR) gene methylation has been shown in different types of glial tumors. Aims and Objectives: This study assessed the RAR beta gene as a potential therapeutic target in gliomas. Materials and Methods: Using in silico methods, potential drugs targeting the RAR beta gene were compared based on temozolomide's effectiveness in treating gliomas. Results and Conclusion: Computational techniques can be used to identify drug-mediated pathways. This in silico study holds promise for RARB and RARB-targeted treatment strategies in gliomas.
Açıklama
Anahtar Kelimeler
Glioma Treatment, RAR Beta, Temozolomide, Promoter Methylation, Stem-Cells, Glioblastoma, Mgmt, Temozolomide, Idh1, Mutations, Pathways, Tool
Kaynak
Neurological Sciences And Neurophysiology
WoS Q Değeri
N/A
Scopus Q Değeri
Q4
Cilt
40
Sayı
3
