The effect of dementia level on body composition and basal metabolic rate in Alzheimer’s disease
Küçük Resim Yok
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pamukkale University
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Purpose: Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by irreversible loss of cognitive functions and has multifactorial etiology. Nutritional disorders in Alzheimer’s disease (AD) patients may lead to an increase in cognitive impairment and subsequent progression of dementia. In this study, we aimed to investigate the relationship of basal metabolic rate (BMR) with weight, body mass index (BMI), lean body mass in AD patients and to clarify the clinical and laboratory findings that may affect BMR. Materials and methods: The clinical and demographic characteristics of 108 patients (44 men, 64 women) were recorded. The patients were divided into two groups according to Clinical Dementia Rating Scale as mild and mild-moderate AD (Group 1, n=84) and moderate and severe AD (Group 2, n=24). The patients’ weight, height, waist circumference measurements and laboratory tests were recorded. The patients’ BMI Quetelet indestia, lean body mass Hume equation and BMH levels were also calculated according to Harris-Henedict equation. Results: The mean age of the patients was 71.6±8.2 years, the mean BMI was 30.6±39.8 kg/m2 and the mean dementia duration was 33.8±29.4 months. No difference was found between Group 1 and Group 2 in terms of gender, age, BMI, waist circumference, dementia duration, whereas lean body mass and BMR levels were found to be lower in moderate and severe AD patients compared to mild stage group (p<0,05). BMI, waist circumference and lean body mass were positively correlated with BMR in AD patients. Lean body mass was found to be an independent factor affecting BMR (?=0.732, p<0,001, OR=11.06, CI 95%11.07-15.9). Conclusion: We found a significant weight loss, especially in lean body mass, that may adversely affect the quality of life in advanced AD patients. It is important to implement proper nutrition and exercise programs from the onset of the disease. © 2021, Pamukkale University. All rights reserved.
Açıklama
Anahtar Kelimeler
Alzheimer's Disease; Basal Metabolic Rate; Dementia
Kaynak
Pamukkale Medical Journal
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
14
Sayı
1
