THE EFFECTS OF METHYLEUGENOL ON THE LIVER, KIDNEY AND SMALL INTESTINE AND ON THE ANTIOXIDANT ENZYMES IN RATS

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dc.authoridCerkezkayabekir, Aysegul/0000-0001-5537-1042
dc.authoridErtan, Figen/0000-0002-7882-3993
dc.authorwosidCerkezkayabekir, Aysegul/Q-6629-2018
dc.contributor.authorKaboglu, Aysegul
dc.contributor.authorErtan, Figen
dc.contributor.authorKizilay, Gulnur
dc.date.accessioned2024-06-12T11:08:27Z
dc.date.available2024-06-12T11:08:27Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractMethyleugenol is a natural, widely used constituent of foods. cosmetics, soaps and shampoos. The purpose of this study was to evaluate the effects of methyleugenol on the liver, kidney and small intestine. Methyleugenol was given by gavage to rats for ten days at doses of 10 mg/kg and 30 mg/kg. In liver, widening of the sinusoidal area, necrotic and hypertrophic hepatocytes, cytoplasmic vacuolization in hepatocytes, degeneration of endothelium, mononuclear cell infiltration, and picnotic nuclei were observed. In kidney, loosing of glomerulus, mononuclear cell infiltration, focal bleeding around tubules, degenerative tubules, epithelial membrane degeneration, hypertrophic epithelial cells, and accumulation of material in proximal tubules were observed. In small intestine, increased mitotic figures in the base of villi, edema in connective tissue, connective-epithelial tissue separation, diminished connective tissue in lamina propria, a foam-like appearance, and leukocyte infiltration were observed. There were no significant changes in superoxide dismutase (SOD) and catalase (CAT) activity, but glutathione peroxidase (GPX) activity was significantly increased in the kidney and small intestine at 30 mg/kg (p<0.05). The amount of total protein was significantly increased in liver (p<0.05). but not changed in the kidney and small intestine. We concluded that the toxic effects of methyleugenol must be evaluated in greater detail.en_US
dc.description.sponsorshipThe Research Fund of Trakya University [TUAF-718]en_US
dc.description.sponsorshipThis study was supported by The Research Fund of Trakya University (Project number: TUAF-718). Statistical analyses of data were performed by Statistic Office of Trakya University. We thank Nesrin Turan, MD for her statistical contribution, and William Murk, BS for his editorial assistance in writing the manuscript.en_US
dc.identifier.endpage490en_US
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue4en_US
dc.identifier.startpage481en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22440
dc.identifier.volume18en_US
dc.identifier.wosWOS:000266029000015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherParlar Scientific Publications (P S P)en_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMethyleugenolen_US
dc.subjectSuperoxide Dismutaseen_US
dc.subjectGlutathione Peroxidaseen_US
dc.subjectCatalaseen_US
dc.subjectSuperoxide-Dismutaseen_US
dc.subjectOxidative Stressen_US
dc.subjectGlutathione-Peroxidaseen_US
dc.subjectMethyl Eugenolen_US
dc.subjectEssential Oilsen_US
dc.subjectFree-Radicalsen_US
dc.subjectCopperen_US
dc.subjectToxicityen_US
dc.subjectMetabolismen_US
dc.subjectCarcinogenicityen_US
dc.titleTHE EFFECTS OF METHYLEUGENOL ON THE LIVER, KIDNEY AND SMALL INTESTINE AND ON THE ANTIOXIDANT ENZYMES IN RATSen_US
dc.typeArticleen_US

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