Curcumin attenuates the organ dysfunction caused by endotoxemia in the rat

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dc.contributor.authorMemis, Dilek
dc.contributor.authorHekimoglu, Sevtap
dc.contributor.authorSezer, Atakan
dc.contributor.authorAltaner, Semsi
dc.contributor.authorSut, Necdet
dc.contributor.authorUsta, Ufuk
dc.date.accessioned2024-06-12T10:58:58Z
dc.date.available2024-06-12T10:58:58Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Curcumin has antioxidant, antitumor, and anti-inflammatory properties. However, it remains unknown whether curcumin has any protective effects on sepsis. The purpose of this study was to demonstrate whether curcumin prevents organ dysfunction in animals with sepsis. Methods: Rats were randomized into four groups. The control group (group I, n = 7) did not receive any treatment. The curcumin group (group II. n = 10) only received 1.2 g/kg of curcumin. Escherichia coli were injected into the remaining groups intraperitoneally after general anesthesia. Five hours after injection, 12 rats received placebo (group III), and 10 rats received 1.2 g/kg of curcumin (group IV) for 7 d. All rats were sacrificed on postsepsis day 8 and it midline laparotomy was performed. Livers, kidneys, and small bowels were excised for evaluation of the degree of inflammation and tissue alterations histopathologically. Results: In the liver, widespread hydropic degeneration of hepatocytes were seen in the sepsis group. There was no hydropic degeneration of hepatocytes and no portal inflammation ill the sepsis/curcumin group. With respect to the small bowel, the sepsis group showed edema and prominent intraepithelial infiltration of neutrophil leucocytes and plasma cells. Inflammation and hyperemia in the lamina propria in the sepsis/curcumin group were less than those in the sepsis group, With respect to the kidneys, the sepsis group showed severe acute tubular necrosis that was more restricted in the sepsis/curcumin group than in the sepsis group. Conclusion: curcumin reduced organ dysfunction in rats with experimentally formed sepsis. We propose that curcumin may he useful in the therapy of organ dysfunction due to sepsis, shock, and other diseases associated with local or systemic inflammation. (C) 2008 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.nut.2008.06.008
dc.identifier.endpage1138en_US
dc.identifier.issn0899-9007
dc.identifier.issn1873-1244
dc.identifier.issue11-12en_US
dc.identifier.pmid18752929en_US
dc.identifier.scopus2-s2.0-53449093510en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1133en_US
dc.identifier.urihttps://doi.org/10.1016/j.nut.2008.06.008
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20271
dc.identifier.volume24en_US
dc.identifier.wosWOS:000260930700011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofNutritionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCurcuminen_US
dc.subjectOrgan Dysfunctionen_US
dc.subjectExperimental Sepsisen_US
dc.subjectNf-Kappa-Ben_US
dc.subjectGene-Expressionen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectLiver-Injuryen_US
dc.subjectInhibitionen_US
dc.subjectActivationen_US
dc.subjectPreventsen_US
dc.subjectSepsisen_US
dc.subjectFutureen_US
dc.subjectDnaen_US
dc.titleCurcumin attenuates the organ dysfunction caused by endotoxemia in the raten_US
dc.typeArticleen_US

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