Relation between Tc-99m sestamibi uptake and biological factors in hyperparathyroidism

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dc.authoridPuyan, Fulya/0000-0001-5853-0109
dc.authoridCermik, Tevfik Fikret/0000-0001-7622-7277
dc.authoridOz Puyan, Fulya/0000-0001-5853-0109
dc.authorwosidPuyan, Fulya/V-7074-2019
dc.authorwosidCermik, Tevfik Fikret/A-9694-2018
dc.authorwosidOz Puyan, Fulya/A-7077-2018
dc.contributor.authorCermik, TF
dc.contributor.authorPuyan, FO
dc.contributor.authorSezer, A
dc.contributor.authorFirat, MF
dc.contributor.authorBerkarda, S
dc.date.accessioned2024-06-12T11:08:27Z
dc.date.available2024-06-12T11:08:27Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the relation between uptake ratios of Tc-99m sestamibi (MIBI) and tumor volume, serum biochemical values (i-PTH, Ca, P) and oxyphil cell content. Materials and Methods: The study population consisted of 19 patients (2 M, 17 F; mean +/- SD: 47 +/- 12 y). Anterior planar images of the neck and chest were acquired early (15 min) and triple late phase (1, 2 and 3-4 h) after intravenous injections of 740 MBq MIBI. Each of the surgical materials was reviewed retrospectively. The percentage of cell type (chief, oxyphil and clear cells) in the tumors was calculated by light microscopy. Results: The uptake ratio obtained from L I (1 hour) phase was found to be higher than the uptake ratio obtained from early phase, and the difference was statistically significant (1.57 +/- 0.34 and 1.43 +/- 0.29, p = 0.004, respectively). There was no significant correlation between uptake ratios that were obtained from 4 different imaging phases and lesion volumes, i-PTH levels and calcium levels (p > 0.05). However, there was a significant adverse correlation between L2 and L3 uptake ratios and serum phosphorus values (r = -0.44, p = 0.04 and r = -0.46, p = 0.04, respectively). Additionally, no significant correlation between MIBI uptake ratios of each imaging phase and the laboratory data, volume of lesion or oxyphil percentage volume was found after the multiple regression analysis (E: p = 0.46, r = 0.49; L1: p = 0.24, r = 0.58; L2: p = 0.27, r = 0.57; L3: p = 0.32, r = 0.55, respectively. There was no correlation between gland oxyphil percentage volume and MIBI uptake ratios (p > 0.05). Conclusion: The results of our study show that the optimal imaging times after intravenous injection of MIBI are 15 minutes and I hour because of the shorter examination time without loss of diagnostic ability. In the present study, there was no significant correlation between MIBI uptake ratios and increased gland volume, or serum Ca and i-PTH levels. Besides, we think that oxyphil cell content may not have a main effect on MIBI uptake and retention. The fact of an adverse relation between phosphorus and MIBI retention in our study suggests that phosphorus level should be considered prior to MIBI imaging.en_US
dc.identifier.doi10.1007/BF03027403
dc.identifier.endpage392en_US
dc.identifier.issn0914-7187
dc.identifier.issue5en_US
dc.identifier.pmid16164195en_US
dc.identifier.scopus2-s2.0-24644481104en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage387en_US
dc.identifier.urihttps://doi.org/10.1007/BF03027403
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22446
dc.identifier.volume19en_US
dc.identifier.wosWOS:000231516100005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJapanese Society Nuclear Medicineen_US
dc.relation.ispartofAnnals Of Nuclear Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMIBIen_US
dc.subjectHyperparathyroidismen_US
dc.subjectOxyphil Cellen_US
dc.subjectCalciumen_US
dc.subjectPhosphorusen_US
dc.subjectParathyroid Scintigraphyen_US
dc.subjectSecondary Hyperparathyroidismen_US
dc.subjectTumor Sizeen_US
dc.subjectTechnetium-99m-Mibien_US
dc.subjectLocalizationen_US
dc.subjectAdenomasen_US
dc.titleRelation between Tc-99m sestamibi uptake and biological factors in hyperparathyroidismen_US
dc.typeArticleen_US

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