The effects of memantine on lipid peroxidation following closed-head trauma in rats

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dc.authoridKiris, Talat/0000-0002-2985-3758
dc.authorwosidKiris, Talat/AAP-4665-2020
dc.contributor.authorÖzsüer, H
dc.contributor.authorGörgülü, A
dc.contributor.authorKiris, T
dc.contributor.authorÇobanoglu, S
dc.date.accessioned2024-06-12T10:56:40Z
dc.date.available2024-06-12T10:56:40Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description.abstractMemantine is an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. Unlike other NMDA antagonists, it has been used clinically for years for the treatment of Parkinson's disease, spasticity, and dementia without serious side effects. We aimed to investigate the therapeutic efficacy of memantine on a closed head trauma model. A total of 132 adult male Sprague-Dawley rats were randomly divided into four groups: sham-operated, control (closed head trauma), sham-vehicle (closed head trauma + saline), treatment (closed head trauma + memantine, 10 mg/kg, i.p.). A cranial impact was delivered to the skull, just in front of the coronal suture, over the left hemisphere, from the height of 7 cm. Saline or memantine were applied 15 min after trauma. Rats were euthanased 0.5, 1, 2, 6, 24, 48 h after trauma. Brain tissue samples were taken 5 mm away from the left frontal pole and also from the corresponding point of the contralateral hemispheres. Malondialdehyde activity (MDA) was considered to reflect the degree of lipid peroxidation. The MDA levels continued to increase for the first 2 h after the injury, then started to decrease gradually. Memantine treatment significantly reduced lipid peroxidation levels in the treatment group compared with other groups (P < 0.01). The findings of the present study indicate that memantine provides beneficial effects after closed head trauma in rats.en_US
dc.identifier.doi10.1007/s10143-004-0374-1
dc.identifier.endpage147en_US
dc.identifier.issn0344-5607
dc.identifier.issn1437-2320
dc.identifier.issue2en_US
dc.identifier.pmid15789251en_US
dc.identifier.scopus2-s2.0-17444380041en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage143en_US
dc.identifier.urihttps://doi.org/10.1007/s10143-004-0374-1
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19881
dc.identifier.volume28en_US
dc.identifier.wosWOS:000227939900012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofNeurosurgical Reviewen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectClosed Head Traumaen_US
dc.subjectExcitatory Aminoaciden_US
dc.subjectLipid Peroxidationen_US
dc.subjectMemantineen_US
dc.subjectReceptor-Mediated Neurotoxicityen_US
dc.subjectConcussive Brain-Injuryen_US
dc.subjectAmino-Acid Releaseen_US
dc.subjectNmda Receptoren_US
dc.subjectNoncompetitive Antagonisten_US
dc.subjectNervous-Systemen_US
dc.subjectFree-Radicalsen_US
dc.subjectGlutamateen_US
dc.subjectDamageen_US
dc.subjectEdemaen_US
dc.titleThe effects of memantine on lipid peroxidation following closed-head trauma in ratsen_US
dc.typeArticleen_US

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