Effects of L-dopa and p-coumaric acid combination on oxidative stress, DNA damage, and mitochondrial apoptosis in neuroblastoma cells

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dc.authoridTurker, Nebiye Pelin/0000-0001-6060-3557
dc.authorwosidTurker, Nebiye Pelin/AAH-3197-2021
dc.contributor.authorTurker, Nebiye Pelin
dc.contributor.authorBakar, Elvan
dc.date.accessioned2024-06-12T11:19:32Z
dc.date.available2024-06-12T11:19:32Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThis study aimed to investigate the effects of levodopa (L-dopa), p-coumaric acid, and combinations in the neuroblastoma (N1E-115) cell. L-dopa and L-dopa plus p-coumaric acid group caused oxidative stress by increasing 12.5 and 3.7-fold in superoxide dismutase gene, 11.5 and 4.8-fold increase in catalase gene, respectively. In L-dopa and L-dopa plus p-coumaric acid application, p21 gene expression increased 1.3-fold and 3.2-fold, and the cell cycle stopped in the G1 phase in response to stress in the treatment groups. In the application of L-dopa plus p-coumaric acid to N1E-115 cells, the BCL-2 gene, which is an apoptosis inhibitor, was suppressed and the BAX gene increased 13-fold compared to the control. As a result, it was determined that the cytotoxic effect of L-dopa plus p-coumaric acid application was less than the individual application of the substances, and p-coumaric acid had an inhibitory effect on L-dopa-induced stress.en_US
dc.identifier.doi10.3329/bjp.v18i2.65531
dc.identifier.endpage57en_US
dc.identifier.issn1991-007X
dc.identifier.issn1991-0088
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85163216991en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage49en_US
dc.identifier.urihttps://doi.org/10.3329/bjp.v18i2.65531
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25243
dc.identifier.volume18en_US
dc.identifier.wosWOS:001015459600002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBangladesh Pharmacological Socen_US
dc.relation.ispartofBangladesh Journal Of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectParkinsons-Diseaseen_US
dc.subjectCanceren_US
dc.subjectBaxen_US
dc.titleEffects of L-dopa and p-coumaric acid combination on oxidative stress, DNA damage, and mitochondrial apoptosis in neuroblastoma cellsen_US
dc.typeArticleen_US

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