Desferrioxamine effectively attenuates testicular tissue at the end of 3 h of ischemia but not in an equal period of reperfusion

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dc.authoridKARACA, Turan/0000-0002-2500-7781;
dc.authorwosidKARACA, Turan/ABD-6669-2020
dc.authorwosidAyaz, Ahmet/I-9910-2019
dc.contributor.authorAyvaz, Suleyman
dc.contributor.authorInan, Mustafa
dc.contributor.authorAksu, Burhan
dc.contributor.authorKaraca, Turan
dc.contributor.authorCemek, Mustafa
dc.contributor.authorAyaz, Ahmet
dc.contributor.authorBasaran, Umit Nusret
dc.date.accessioned2024-06-12T11:15:28Z
dc.date.available2024-06-12T11:15:28Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: To investigate the effect of desferrioxamine (DFX) on ipsilateral and contralateral testis damage caused by experimental testis torsion and detorsion. Materials and methods: Forty rats were divided into five groups (n = 8): control, torsion (T), torsion + desferrioxamine (T + DFX), torsion/detorsion (T/D), and torsion/detorsion + desferrioxamine (T/D + DFX). The right testes of the rats were subjected to torsion and detorsion for 3 h each. Thirty minutes before the application of torsion and detorsion, DFX (100 mg/kg) was administered intramuscularly. Blood samples and testicular tissues were examined using specific biochemical and histopathological methods. Results: Ipsilateral and contralateral testis tissue glutathione levels in the T group decreased compared with the control and T + DFX groups. Plasma glutathione peroxidase activity in the T, T/D, and T/D + DFX groups was lower than in the control group. Plasma catalase activity in the T and T/D groups decreased compared with the control group. Ipsilateral mean seminiferous tubule diameter of the T group was lower than that of the T + DFX group. The ipsilateral mean testis biopsy scores in the T and T/D groups were lower than in the control group. Conclusion: The administration of DFX prior to torsion may be useful only for preventing ischemic damage in ipsilateral and contralateral testes. (C) 2013 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.jpurol.2013.11.019
dc.identifier.endpage558en_US
dc.identifier.issn1477-5131
dc.identifier.issn1873-4898
dc.identifier.issue3en_US
dc.identifier.pmid24440694en_US
dc.identifier.scopus2-s2.0-84902280819en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage550en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpurol.2013.11.019
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23954
dc.identifier.volume10en_US
dc.identifier.wosWOS:000339771000032en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofJournal Of Pediatric Urologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSpermatic Cord Torsionen_US
dc.subjectIschemiaen_US
dc.subjectReperfusion Injuryen_US
dc.subjectSpermatic Cord Torsionen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectSuperoxide-Dismutaseen_US
dc.subjectBlood-Flowen_US
dc.subjectInjuryen_US
dc.subjectDeferoxamineen_US
dc.subjectAntioxidantsen_US
dc.subjectPretreatmenten_US
dc.subjectGlutathioneen_US
dc.subjectDesferroxamineen_US
dc.titleDesferrioxamine effectively attenuates testicular tissue at the end of 3 h of ischemia but not in an equal period of reperfusionen_US
dc.typeArticleen_US

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