Hipertansiyonlu hastalarda ACE gen polimorfizminin araştırılması
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Dosyalar
Tarih
2006
Yazarlar
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Yayıncı
Trakya Üniversitesi Sağlık Bilimleri Enstitüsü
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Hipertansiyon, önemli bir sağlık problemidir. Kan basıncı ve tuz dengesi üstündeki renin-angiotensin sistemi sayesinde düzenlenir. Angiotensin Converting Enzim (ACE)'de bu sisteme ait bir enzimdir. ACE İnsertion / Deletion (I/D) polimorfizmi çeşitli kardiovasküler hastalıklarda önemli olduğu gösterilmiştir. Fakat ACE I/D polimorfizminin hipertansiyonda rolü olduğunu gösteren çalışmalar olmakla birlikte hipertansiyona etkisi olmadığını gösteren çalışmalarda mevcuttur. Çalışmamızda 79 hipertansiyonlu hasta ve 38 kontrol gurubunda Polimeraz Zincir Reaksiyonu (PCR) ve agaroz jel sistemi ile ACE I/D polimorfizmi çalışıldı. Erkek hasta ve kontrol guruplarında genotip dağılımları normal bulundu. ACE Deletion / Deletion (DD) genotipi kadın hasta gurubunda (%35.5) anlamlı şekilde kontrol gurubuna göre yüksek bulundu (%21.4). Bu sonuçlara göre ACE DD genotipi kadınlarda hipertansiyon ile ilişkili olduğu gösterildi ancak bu fark erkeklerde gösterilemedi.
Hypertension is common healt problem. The renin aniotensin system (RAS) helps maintain blood pressure and salt homeostasis appears important in the hypertension. Angiotensin Converting Enzyme (ACE) a key component of RAS. Insertion/Deletion polymorphism of ACE gene has been implicated in the pathonesis of cardiovascular diseases. In addition to this, the association between ACE I/D polymorphism and hypertension is controversial, when numerous studies have addressed the role of ACE I/D polymorphism the development of hypertension, there were different studies showed that no corelation has been found between ACE I/D polymorphism and development of hypertension. We analyzed the ACE gene ACE I/D polymorphism in 79 patients with hyperension group and 38 age matched healthy individiuals as a control goup by using a polymerase chain reaction assay, and agarose gel electrophoresis system. The genotype distribution were no different between the patients and normal control groups in the men. But the frequency of ACE Deletion /Deletion (DD) genotype in patients with hyperension (35.5%) was significantly higher than in controls (21.4%) in he women.
Hypertension is common healt problem. The renin aniotensin system (RAS) helps maintain blood pressure and salt homeostasis appears important in the hypertension. Angiotensin Converting Enzyme (ACE) a key component of RAS. Insertion/Deletion polymorphism of ACE gene has been implicated in the pathonesis of cardiovascular diseases. In addition to this, the association between ACE I/D polymorphism and hypertension is controversial, when numerous studies have addressed the role of ACE I/D polymorphism the development of hypertension, there were different studies showed that no corelation has been found between ACE I/D polymorphism and development of hypertension. We analyzed the ACE gene ACE I/D polymorphism in 79 patients with hyperension group and 38 age matched healthy individiuals as a control goup by using a polymerase chain reaction assay, and agarose gel electrophoresis system. The genotype distribution were no different between the patients and normal control groups in the men. But the frequency of ACE Deletion /Deletion (DD) genotype in patients with hyperension (35.5%) was significantly higher than in controls (21.4%) in he women.
Açıklama
Yüksek Lisans Tezi
Anahtar Kelimeler
Angiotensin Converting Enzim, Hipertansiyon, Polimorfizm, Angiotensin Converting Enzyme, Hypertension, Polymorphism
