Effects of dexmedetomidine infusion on hemodynamic responses in craniotomies

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dc.authorscopusid6603397675
dc.authorscopusid7004931815
dc.authorscopusid7006498929
dc.authorscopusid15831874100
dc.authorscopusid6701467427
dc.authorscopusid8560325700
dc.contributor.authorAlagöl A.
dc.contributor.authorKaya G.
dc.contributor.authorÇolak A.
dc.contributor.authorKaraçayir Y.
dc.contributor.authorPamukçu Z.
dc.contributor.authorTuran F.N.
dc.date.accessioned2024-06-12T10:28:59Z
dc.date.available2024-06-12T10:28:59Z
dc.date.issued2006
dc.description.abstractAim: The effectiveness of dexmedetomidine infusion on preventing hemodynamic response to intubation, skull pins and surgical incision in craniotomies was evaluated. Materials and Methods: Fourty ASA I-II patients undergoing craniotomy because of supratentorial tumors were randomised into: study group (n=20) received 1 ?g kg h-1 dexmedetomidine, and control group (n=20) received 0.9% NaCl infusion, 5 min. prior to induction. After intubation was performed at 10th minute, infusion rates were reduced to 50% in both groups. Control group received 1 ?g kg-1 fentanyl; dexmedetomidine group received 0.9% NaCl intravenously before skull pins. Same drugs were administered to the both groups for premedication, induction and maintenance. Results: Heart rate, systolic and diastolic arterial pressures reduced at 5th minute of infusion compared to initial values in dexmedetomidine group (p<0.001). Systolic and diastolic arterial pressures reduced after induction in both groups (p<0.001). In control group, the three haemodynamic parameters were higher after intubation compared to before intubation (p<0.001); were higher at 1 (p<0.001) and 5 minutes (p<0.05) after skull pins compared to before intubation; heart rate, systolic and diastolic (p<0.05) arterial pressures were higher after surgical incision compared to before intubation (p<0.001). In dexmedetomidine group, intubation and surgical incision did not cause significant haemodynamic response; systolic (p<0.001) and diastolic (p<0.05) arterial pressures were lower at 5 th minute than 1st minute of skull pins. Six patients in control and no patients in dexmedetomidine group needed fentanyl after surgical incision (p<0.001). Conclusion: Dexmedetomidine infusion started before induction is effective for preventing haemodynamic responses to intubation, skull pins and surgical incision in craniotomies.en_US
dc.identifier.endpage240en_US
dc.identifier.issn1304-0871
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-33846518369en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage236en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17524
dc.identifier.volume34en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofTurk Anesteziyoloji ve Reanimasyon Dernegi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCraniotomy; Dexmedetomidine; Haemodynamic Response; Incision; Intubation; Skull Pinsen_US
dc.subjectDexmedetomidine; Fentanyl; Sodium Chloride; Article; Clinical Article; Clinical Trial; Controlled Clinical Trial; Controlled Study; Craniotomy; Diastolic Blood Pressure; Drug Effect; Heart Rate; Hemodynamics; Human; Randomized Controlled Trial; Systolic Blood Pressureen_US
dc.titleEffects of dexmedetomidine infusion on hemodynamic responses in craniotomiesen_US
dc.title.alternativeKraniyotomilerde deksmedetomidin i?nfüzyonunun hemodinamik yanitlar üzerine etkisien_US
dc.typeArticleen_US

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