Evaluation of the factors affecting survival and local recurrence in thigh soft tissue sarcomas

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dc.authoridCiftdemir, Mert/0000-0002-9677-2819
dc.authoridyildirim, savas/0000-0003-0677-4720
dc.contributor.authorYildirim, Savas
dc.contributor.authorCiftdemir, Mert
dc.contributor.authorUstabasioglu, Fethi Emre
dc.contributor.authorUstun, Funda
dc.contributor.authorUsta, Ufuk
dc.date.accessioned2024-06-12T11:07:46Z
dc.date.available2024-06-12T11:07:46Z
dc.date.issued2024
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: The aim of this study was to evaluate the factors affecting local recurrence and survival in patients with soft-tissue sarcomas located in the thigh.Patients and methods: This retrospective cross-sectional study evaluated 41 soft tissue sarcoma patients (21 males, 20 females; mean age: 57.9 +/- 13.7 years; range, 18 to 90 years) with thigh involvement between January 2010 and December 2020. All surgical intervention was performed by one surgeon with an experience of 15 years in orthopedic oncologic surgery. Epidemiological, radiological, histopathological, and metabolic features, as well as surgical and oncological treatments and prognoses, were assessed. The data was statistically analyzed to determine factors affecting local recurrence and survival in these cases, staged using Enneking and the American Joint Committee on Cancer classifications.Results: Liposarcomas were the most common type of tumor (39%), followed by undifferentiated pleomorphic sarcomas (32%). Tumors >10 cm were associated with decreased survival rates. High-grade tumors, tumor necrosis, Ki-67 index >20%, and positive surgical margins were also associated with lower survival rates. Metastatic patients had significantly lower survival rates. Local recurrence was significantly more frequent in patients with positive surgical margins. Survival rates were significantly lower in metastatic patients.Conclusion: There are many factors that affect local recurrence and survival of soft tissue sarcomas. The size of the mass, the presence of necrosis, a high Ki-67 index, positive surgical margins, and the presence of metastasis are the main factors that should be taken into consideration.en_US
dc.identifier.doi10.52312/jdrs.2023.1289
dc.identifier.endpage137en_US
dc.identifier.issn2687-4792
dc.identifier.issue1en_US
dc.identifier.pmid38108174en_US
dc.identifier.scopus2-s2.0-85180384784en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage130en_US
dc.identifier.trdizinid1227234en_US
dc.identifier.urihttps://doi.org/10.52312/jdrs.2023.1289
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1227234
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22180
dc.identifier.volume35en_US
dc.identifier.wosWOS:001110699300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Joint Diseases Foundationen_US
dc.relation.ispartofJoint Diseases And Related Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLocal Recurrenceen_US
dc.subjectSoft Tissue Sarcomaen_US
dc.subjectSurvivalen_US
dc.subjectThighen_US
dc.subjectAdjuvant Radiation-Therapyen_US
dc.subjectPrognostic Valueen_US
dc.subjectSurgical Marginen_US
dc.subjectClassificationen_US
dc.subjectNecrosisen_US
dc.subjectPredictsen_US
dc.titleEvaluation of the factors affecting survival and local recurrence in thigh soft tissue sarcomasen_US
dc.typeArticleen_US

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