A morphological study on Leydig cells of scrotal hyperthermia applied rats in short-term

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dc.authorwosidAktas, Cevat/D-8468-2011
dc.contributor.authorAktas, Cevat
dc.contributor.authorKanter, Mehmet
dc.date.accessioned2024-06-12T11:03:42Z
dc.date.available2024-06-12T11:03:42Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractTesticular function is highly dependent on temperature control. The aim of this study was designed to investigate the morphological changes and regulation of steroidogenesis by light and electron microscopic level in Leydig cells (LC) after scrotal hyperthermia in rats. The rats were randomly allotted into one of four experimental groups: A (Control), B (1 day after scrotal hyperthermia), C (14 days after scrotal hyperthermia), D (35 days after scrotal hyperthermia); each group contain seven animals. Scrotal hyperthermia was carried out in a thermostatically controlled water bath at 43A degrees C for 30 min once daily for 6 consecutive days. Control rats were treated in the same way, except the testes were immersed in a water bath maintained at 22A degrees C. Hyperthermia applied rats were sacrificed under 50 mg/kg ketamine anaesthesia after 1, 14 and 35 days, and biopsy materials of testis were obtained for light and electron microscopic examinations. To date, no histopathological changes of LC injury after scrotal hyperthermia in rats have been reported. Light microscopic examinations indicated increase degenerative LC, decrease in number of testosterone positive LC in interstitial area after scrotal hyperthermia in short-term. In scrotal hyperthermia, a dilated smooth endoplasmic reticulum, swollen mitochondria, and vanished mitochondrial cristae were observed. The nuclei of some LC displayed deep invaginations and irregular outlines. The number of lipid droplets was very considerably increased in most LC when compared to control group. As a conclusion, we claim that temperatures higher than the body temperature may cause infertility by damaging LC.en_US
dc.identifier.doi10.1007/s10735-009-9210-9
dc.identifier.endpage39en_US
dc.identifier.issn1567-2379
dc.identifier.issn1567-2387
dc.identifier.issue1en_US
dc.identifier.pmid19184471en_US
dc.identifier.scopus2-s2.0-67749086340en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage31en_US
dc.identifier.urihttps://doi.org/10.1007/s10735-009-9210-9
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21762
dc.identifier.volume40en_US
dc.identifier.wosWOS:000264485300004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Molecular Histologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectImmunohistochemistryen_US
dc.subjectUltrastructureen_US
dc.subjectLeydig Cellen_US
dc.subjectScrotal Hyperthermiaen_US
dc.subjectRaten_US
dc.subjectAcute Regulatory Proteinen_US
dc.subjectTesticular Blood-Flowen_US
dc.subjectAdult Male-Ratsen_US
dc.subjectExperimental Cryptorchidismen_US
dc.subjectSteroidogenic Enzymesen_US
dc.subjectImmobilization Stressen_US
dc.subjectSeminiferous Tubulesen_US
dc.subjectMale-Miceen_US
dc.subjectIn-Vivoen_US
dc.subjectTestisen_US
dc.titleA morphological study on Leydig cells of scrotal hyperthermia applied rats in short-termen_US
dc.typeArticleen_US

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